Ontology highlight
ABSTRACT:
PROVIDER: PRJEB34885 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| ERR3618175_1.fastq.gz | Fastqsanger.gz | |||
| ERR3618175_2.fastq.gz | Fastqsanger.gz | |||
| ERR3618176_1.fastq.gz | Fastqsanger.gz | |||
| ERR3618176_2.fastq.gz | Fastqsanger.gz | |||
| ERR3618177_1.fastq.gz | Fastqsanger.gz |
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Project description:Genomic changes associated with resistance to the pyrethroid insecticide deltamethrin were investigated between six mosquito lines all originating from La Reunion Island. Two of these 6 lines, Sel and NS, derived from the same composite population made by pooling six distinct field populations from La Reunion Island: in the lab, the Sel line was subjected to deltamethrin selection for five successive generations at the adult stage while the NS line was maintained without selection. Three lines correspond to field populations collected in 2018-2029 in three distinct localities (SL: Saint-Louis, SP: Saint Pierre, SS: Sainte-Suzanne. Finally, the susceptible line SRun originating collected in the early 2000s from La Réunion island and maintained in the laboratory since then was also used as a reference.
2026-06-26 | E-MTAB-15456 | biostudies-arrayexpress
Project description:Gene expression changes were investigated between six mosquito lines originating from La Reunion Island and correlated with their differential deltamethrin resistance levels. Two of these 6 lines derived from a composite population made by pooling six distinct field populations from La Reunion Island: the Sel line was subjected to deltamethrin selection for five successive generations at the adult stage while the NS line was maintained without selection. Three field populations collected in 2018-2029 in three distinct localities (SL: Saint-Louis, SP: Saint Pierre, SS: Sainte-Suzanne) were also used. Finally, the susceptible line SRun originating collected in the early 2000s from La Réunion island and maintained in the laboratory since then was also used as a reference. For each line, four replicate transcriptomes were generated from 5-days old non-blood fed adult females.
2026-06-25 | E-MTAB-15418 | biostudies-arrayexpress
Project description:Genome sequencing of the blood attributed to King Louis XVI
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Project description:Immune tolerance is involved physiologically in pregnancy and disrupted in autoimmunity, organ rejection, and graft-versus-host disease (GvHD). In transplantation setting, operational tolerance has been inferred in patients who develop tolerance without a need for immunosuppressants. However, mechanisms underlying operational tolerance in Humans are poorly understood. Using two cohorts of patients who underwent an allo-HSCT from HLA-identical siblings, we used multi-omics approach to decipher immune landscape associated with tolerance in recipients and their related donors. We analyzed two cohorts of patients, one monocentric from Saint Louis hospital (cohort 1, n=41) and one multicenric from the national Cryostem consortium biological collection (cohort 2, n=69). We proceed to deep immunophenotyping of peripheral blood mononuclear cell using mass cytometry, RNA sequencing analysis and metabolomics profiling of plasma in both recipients and related donors. The aim of this study is to determine the evolution of immune landscape after allogeneic HSCT by comparison with healthy donors, and to identify specific biological mechanism associated with immune tolerance in patients.
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Project description:We applied an effects-based approach to determine if the impact of specific chemicals in mixtures discharged by waste water treatment plants could be linked to well-defined gene expression changes in exposed fish. Fathead minnows were deployed in cages for 2, 4, or 8 days at three locations near two WWTP discharge sites in the Saint Louis Bay, Duluth, MN and one upstream control site. The impact of 51 chemicals detected in the surface water on gene expression in ovaries of caged fish was determined using exposure activity ratios, existing knowledge on chemical:gene relationships, and analysis of gene expression co-variance with surface water chemistry. Thirty-two chemicals could be linked to gene expression and 12 were confirmed by other sources such as the Comparative Toxicogenomics Database (CTD). Chemical:gene associations determined by co-variation were supported by exposure activity ratios sufficient to cause biological effects, known chemical:gene associations from CTD, and upstream regulator analysis of the Ingenuity knowledge base. The analyses provided multiple lines of evidence that bisphenol A and estrone are likely sources of estrogenic effects on gene expression found at the study sites.
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Project description:A "Cartes d'Identite des Tumeurs" (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net). 104 samples; Affymetrix U133A micro-arrays.<br> <br> Ninety two patients with T-ALL were diagnosed and treated at Saint-Louis hospital, Paris. Seven patients were studied at diagnosis and relapse (total 99 T-ALL samples). There were 56 children (median age 9 years old; range 1 to 16), and 36 adults (median age 27; range 17 to 66). Informed consent was obtained from the patients and/or relatives. T-ALL diagnosis was based on morphological and immunophenotypical criteria using flow cytometry and an extended monoclonal antibody panel.<br> <br> Using a combination of molecular cytogenetic and large-scale expression analysis in human T-ALL, we identified and characterized a new recurrent chromosomal translocation, targeting the major homeobox gene cluster HOXA and the TCRB locus. Specific quantitative PCR analysis showed that the expression of the whole HOXA gene cluster was dramatically dysregulated in the HOXA-rearranged cases, and also in MLL and CALM-AF10-related T-ALL cases, strongly suggesting that HOXA genes are oncogenic in these leukemias. Inclusion of HOXA-translocated cases in a general molecular portrait of 92 T-ALL based on large-scale expression analysis shows that this rearrangement defines a new homogeneous subgroup, which shares common biological networks with the TLX1 and TLX3-related cases. Since T-ALLs derive from T-cell progenitors, expression profiles of the distinct T-ALL subgroups were analyzed with respect to those of normal human thymic sub-populations. Inappropriate utilization or perturbation of specific molecular networks involved in thymic differentiation was detected. Moreover, we found a significant association between T-ALL oncogenic subgroups and ectopic expression of a limited set of genes, including several developmental genes, namely HOXA, TLX1, TLX3, NKX3-1, SIX6 and TFAP2C. These data strongly support the view that the abnormal expression of developmental genes, including the prototypical homeobox genes HOXA, is critical in T-ALL oncogenesis.<br> <br> Project Leader: <br> FranC'ois Sigaux<br> Institut Universitaire d'Hematologie<br> Hopital Saint Louis, Paris, France<br> <br> Data submission:<br>Fabien Petel
2005-04-15 | E-MEXP-313 | biostudies-arrayexpress
Project description:Judith, great-granddaughter of Charlemagne, was born ca. 843 to King Charles the Bald of West Francia and his wife Ermentrudis. Around the age of 13, in late 856, she was married to King Aethelwulf of Wessex and crowned queen, and upon his death married his son, Aethelbold. When he died, two years later, she moved back to France. In France, she became acquainted with Baldwin, an aristocrat, and eloped with him. After her father condoned her marriage to Baldwin, she became the first Countess of Flanders and co-founder of the dynasty of the Counts of Flanders. The whereabouts of the grave of Judith are still unknown from historic sources. In 2006, upon the excavation of the square in front of Saint-Peter’s abbey church, an elite burial cluster was found containing two females, a male, and four children. Carbon dating and a basic anthropological analysis led to historians suggesting that the remains of the oldest female, S127, could be those of Judith, yet this hypothesis was not tested further at the time. The current study tests this archaeo-historic possibility through multidisciplinary analysis of the skeletal remains. The skeletal, dental, and stable isotope analyses suggest the individual had a privileged childhood but that in her later years, S127 did suffered from a number of pathologies that would have caused her daily discomfort. Proteomic analysis confirmed the macroscopic sex estimation of the adults and provided sex information for the child and infant remains. Ancient DNA preservation was insufficient to provide any relevant information. The sStrontium isotope analysis does not contradict the geographical movements of Judith identified by the historians. It cannot therefore not be excluded that the skeleton in grave S127 is that of Judith, Queen of Wessex, first Countess of Flanders.
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