Project description:Comparable plasma lipid changes in patients with high-grade cervical intraepithelial neoplasia and patients with cervical cancer

2020-10-22 | MSV000086351 | GNPS

human vaginal metagenome

Project description:5R 16S rRNA sequencing of cervical tissue before and after LEEP in cervical intraepithelial neoplasia (CIN) patients (PRJCA035188)

| PRJDB34247 | ENA

Proteomic alterations in early stage cervical cancer

Project description:Cervical cancer is characterized by a well-defined pre-malignant phase, cervical intraepithelial neoplasia (CIN). Identification of high grade CIN lesions by population-based screening programs and their subsequent treatment has led to a significant reduction of the incidence and mortality of cervical cancer. Cytology-based testing of cervical smears is the most widely used cervical cancer screening method, but is not ideal, as the sensitivity for detection of CIN2 and higher (CIN2+) is only ~55%. Therefore, more sensitive and specific biomarkers for cervical cancer and its precancerous stages are needed.

2018-05-03 | PXD008723 | Pride

Metaproteomics of Vaginal Secretion from Squamous Intraepithelial Lesion Patients

Project description:In this study, 172 HPV-positive patients were enrolled, of which 103 were diagnosed with low-grade squamous intraepithelial lesion (LSIL) and 69 with high-grade squamous intraepithelial lesion (HSIL). Vaginal secretions of these patients were collected for metaproteomic analysis.

2025-09-19 | PXD068641 |

Pre-invasive versus microinvasive carcinoma of the cervix

Project description:Comparative analysis of gene expression prodfiles of cervical biopsy from two (2) patients with pre-invasive neoplastic lesions (carcinonma in citu, or high-grade cervical intraepithelial neoplasia) and 2 patients with earliest stage of invasive cancer

2018-12-22 | GSE124288 | GEO

Direct on-swab metabolic profiling of vaginal microbiome:host interactions during pregnancy and preterm birth

Project description:The pregnancy vaginal microbiome contributes to risk of preterm birth, the primary cause of death in children under 5 years of age. Here we describe direct on-swab metabolic profiling by Desorption Electrospray Ionization Mass Spectrometry (DESI-MS) for sample preparation-free characterisation of the cervicovaginal metabolome in two independent pregnancy cohorts (VMET, n = 160; 455 swabs; VMET II, n = 205; 573 swabs). By integrating metataxonomics and immune profiling data from matched samples, we show that specific metabolome signatures can be used to robustly predict simultaneously both the composition of the vaginal microbiome and host inflammatory status. In these patients, vaginal microbiota instability and innate immune activation, as predicted using DESI-MS, associated with preterm birth, including in women receiving cervical cerclage for preterm birth prevention. These findings highlight direct on-swab metabolic profiling by DESI-MS as an innovative approach for preterm birth risk stratification through rapid assessment of vaginal microbiota-host dynamics. Linked cross omic data sets:Meta-taxonomics data associated with this study are available in the European Nucleotide Archive (ENA): accession number <a href='https://www.ebi.ac.uk/ena/browser/view/PRJEB11895' rel='noopener noreferrer' target='_blank'>PRJEB11895</a>, <a href='https://www.ebi.ac.uk/ena/browser/view/PRJEB12577' rel='noopener noreferrer' target='_blank'>PRJEB12577</a> and <a href='https://www.ebi.ac.uk/ena/browser/view/PRJEB41427' rel='noopener noreferrer' target='_blank'>PRJEB41427</a>.

2021-09-23 | MTBLS717 | MetaboLights

human vaginal metagenome

Project description:5R 16S rRNA sequencing of cervical tissue among healthy HPV-negative controls (NC), HPV-positive controls (NH), and cervical intraepithelial neoplasia (CIN) groups (PRJCA035186)

| PRJDB34246 | ENA

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