Proteomic alterations in early stage cervical cancer
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Uterine Cervix
SUBMITTER: 
Coskun Guzel
LAB HEAD: Theo M. Luider
PROVIDER: PXD008723 | Pride | 2018-05-03
REPOSITORIES: Pride
Publications
Proteomic alterations in early stage cervical cancer.
Güzel Coşkun C Govorukhina Natalia I NI Wisman G Bea A GBA Stingl Christoph C Dekker Lennard J M LJM Klip Harry G HG Hollema Harry H Guryev Victor V Horvatovich Peter L PL van der Zee Ate G J AGJ Bischoff Rainer R Luider Theo M TM
Oncotarget 20180406 26
Laser capture microdissection (LCM) allows the capture of cell types or well-defined structures in tissue. We compared in a semi-quantitative way the proteomes from an equivalent of 8,000 tumor cells from patients with squamous cell cervical cancer (SCC, <i>n</i> = 22) with healthy epithelial and stromal cells obtained from normal cervical tissue (<i>n</i> = 13). Proteins were enzymatically digested into peptides which were measured by high-resolution mass spectrometry and analyzed by "all-or-no ...[more]
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