Project description:The domestic ferret has recently been described as a uniformly lethal model of infection for three species of Ebolavirus known to be pathogenic to humans. Reagents to systematically analyze the ferret host response to infection are lacking; however, the recent publication of a draft ferret genome has opened the potential for transcriptional analysis of ferret models of disease. In this work, we present comparative analysis of longitudinally sampled blood taken from ferrets and non-human primates infected with lethal doses of the Makona strain of Zaire ebolavirus. Strong induction of proinflammatory and prothrombotic signaling programs were present in both ferrets and non-human primates and both transcriptomes were similar to previously published datasets of fatal cases of human Ebola virus infection.

2018-08-26 | GSE115620 | GEO

Trichuris trichiura

Project description:Trichuris trichiura complete mitogenome - South Korea

| PRJNA823754 | ENA

Studies on genomic imprinting in preimplantation embryos of non-human primates [WGBS]

Project description:Genomic imprinting resulted by asymmetric epigenome of parents is a conserved phenomenon restricting biased expression of genes on two alleles. Disorder of imprinting can cause severe defects and diseases. In mouse and human, most of imprinted genes are expressed in species-specific and tissue-specific style. Here, rhesus monkeys as non-human primates are used to investigate primate genomic imprinting. We got a novel candidate canonical imprinted genes list in genome-wide by integrated analysis of allele-specific DNase I hypersensitive sites, differential expressed genes and differential DNA methylation. Further analysis revealed that both DNA methylation and H3K27me3 have an effect on the expression of imprinted genes. Consistent with human, analysis of H3K27me3 showed that H3K27me3 undergoes reprogramming in pre-implantation. Thus, our data provides a genome-wide view of genomic imprinting in non-human primates and sheds light on the further understanding of epigenetic programming process of monkey.

2025-12-22 | GSE180571 | GEO

Pathogenesis of influenza A(H7N9) virus in aged non-human primates

Project description:Pathogenesis of influenza A(H7N9) virus in aged non-human primates

| PRJNA639175 | ENA

Studies on genomic imprinting in preimplantation embryos of non-human primates

Project description:Studies on genomic imprinting in preimplantation embryos of non-human primates

| PRJNA748717 | ENA