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ATAC-seq of human oesophageal adenocarcinoma OE19 cell line treated with lapatinib for 35 days followed by drug withdrawal

ABSTRACT: ATAC-seq of human oesophageal adenocarcinoma OE19 cell line treated with lapatinib for 35 days followed by drug withdrawal

PROVIDER: PRJEB44103 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR5646990_1.fastq.gz	Fastqsanger.gz
	ERR5646990_2.fastq.gz	Fastqsanger.gz
	ERR5646991_1.fastq.gz	Fastqsanger.gz
	ERR5646991_2.fastq.gz	Fastqsanger.gz
	ERR5646992_1.fastq.gz	Fastqsanger.gz

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ATAC-seq of human oesophageal adenocarcinoma OE19 cell line treated with lapatinib for 35 days followed by drug withdrawal

Project description:To investigate whether changes to chromatin accessibility associated with resistance to lapatinib are a stable or a reversible state, we treated OE19 cells with 500 nM lapatinib for 35 days and then withdrew lapatinib for 1, 2, 3 and 14 days. Control cells treated with DMSO for 1 day and 'resistant' cells treated with 500 nM lapatinib for 35 days were also sequenced.

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