Project description:A panel of 17 human melanoma cell lines with known BRAF and NRAS mutation status was stimulated with TNF-alpha for 72 hours. The goal of the study was to correlate the transcriptional response in BRAF versus NRAS mutated melanoma cell lines. Total RNA was obtained from a panel of 17 human melanoma cell lines treated for 72 hours with TNF-alpha or left untreated. Gene expression profiling was done using the Illumina Human HT12 v4 platform.

2014-02-10 | E-GEOD-51221 | biostudies-arrayexpress

Project description:Illumina RNA-sequencing of MIKK medaka liver samples

| PRJEB43091 | ENA

Targeted RNA Sequencing of a panel of ovarian cancer cell lines

Project description:Assess the baseline expression of the genes in the Oncology Biomarker Panel across the panel of ovarian and cervical cancer cell lines. This data will then be compared to the sensitivity of the cell lines to DDR inhibitors. The expression data will be correlated with the sensitivity of the cell lines to see whether determinants of sensitivity described in the literature translate. A hierarchy of genes will be determined. It is expected that the cells that are more sensitive to DDR inhibitors will have decreased expression of the genes known to be determinants of sensitivity.

2020-05-21 | GSE150942 | GEO

Protein profile in a panel of HEK293A cell lines with genetic deletion

Project description:MS Analysis of genetic KO in a panel of HEK293A cell lines with genetic deletion

2023-03-04 | PXD030368 | Pride

RNA-Seq of a panel of human lymphoma cell lines (B cells)

Project description:We invastigated the baseline transcriptomic profiles of a panel of B-cell lymphoma cell lines

2023-05-10 | GSE221770 | GEO

Project description:Nanopore DNA-seq of MIKK medaka brain samples

| PRJEB43089 | ENA

Identification of transcripts harboring premature termination codons by NMD inhibition in a panel of CCRCC cell lines

Project description:Identification of transcripts harbouring premature termination codons by NMD inhibition (GINI method) in a panel of clear cell renal cell carcinoma cell lines. Sporadic clear cell renal cell carcinoma (cRCC) is genetically characterized by the recurrent loss of chromosome 3p, with a hotspot for copy number loss in the 3p21 region. In this study, we applied a method called Gene Identification by Nonsense Mediated mRNA decay Inhibition (GINI) on a panel of 10 cRCC cell lines with 3p21 copy number loss to identify biallelic inactivated genes located at 3p21. This analysis revealed inactivation of the histone methyltransferase gene SETD2, located on 3p21.31, as a common event in cRCC cells. SETD2 is nonredundantly responsible for trimethylation of the histone mark H3K36. Consistent with this function, we observed loss or decrease of H3K36me3 in 7 out of 10 cRCC cell lines. Identification of missense mutations in 2 of 10 primary cRCC tumor samples further supported the involvement of loss of SETD2 function in the development of cRCC tumors.

2010-02-25 | GSE20491 | GEO

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