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Single cell analysis of CD45 positive cells isolated from MC38 colon carcinoma tumor-bearing C57BL/6 mice

ABSTRACT: Single cell analysis of CD45 positive cells isolated from MC38 colon carcinoma tumor-bearing C57BL/6 mice

PROVIDER: PRJEB45601 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR6043820.fastq.gz	Fastqsanger.gz
	ERR6043821.fastq.gz	Fastqsanger.gz
	ERR6043822.fastq.gz	Fastqsanger.gz
	ERR6043823.fastq.gz	Fastqsanger.gz
	ERR6043824.fastq.gz	Fastqsanger.gz

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Project description:RNA-sequencing was performed on sorted CD11b-CD11c-B220-CD45+TCRbeta+CD44+CD8+ TIL from vehicle or JHU083 treated MC38 tumor-bearing mice with or without JHU083, pro-drug of 6-Diazo-5-oxo-L-norleucine (glutamine antagonist) treatment for expression profiling

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Single-cell RNAseq of CD45 positive cells in MC38 tumors - Primary irradiated tumors and secondary non-irradiated tumors - Concurrent treatment with anti-PD-L1

Project description:Primary irradiated MC38 tumors and secondary MC38 non-irradiated tumors. Subcutaneous MC38 tumors in C57BL/6 mice Concurrent treatment with anti-PD-L1.

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Transcriptional analysis of CD45+ leukocytes isolated from syngeneic MC38 tumors from mice fed high-fat or control diet

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Single cell TCR-seq profiling of T cells isolated from LNs of MC38 tumor-bearing mice

Project description:We investigate the single-cell landscape of the inflammatory mouse tumor model MC38, a C57BL/6 tumor cell line derived from colon adenocarcinoma. MC38 (diluted in HBSS and matrigel) was inoculated in the right unilateral flank (in the border of positions B2 and B3) of C57BL/6 mice (ref Study 16-3384 AV). Draining lymph nodes were taken one day after group-out (average 150-250 mm3 tumor size at day 0), approximately 14-19 days. Draining lymph nodes were dissociated and flow sorted accordingly to obtain the cells for 10x Chromium 5' Gene Expression Profiling and TCR sequencing.

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Single cell RNA-seq profiling of T cells isolated from LNs of MC38 tumor-bearing mice

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scRNA-Seq of MC38 CD45+ Cells treated with EZH2 inhibitor PF-06821497

Project description:The purpose of this study was to determine the effect of EZH2 inhibitor (EZH2i) PF-06821497 on CD45+ cells isolated from MC38 tumors at day 17 post implantation. Mice were either treated for 7 days prior to endpoint or 16 days prior to endpoint with the EZH2i or with vehicle control. CD45+ cells were isolated and scRNA-Seq was performed on cells

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Single-cell RNA-seq of MC38 tumor model

Project description:Single-cell RNA-seq was performed on CD45+ and T cells sorted from MC38 tumors from mice.

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Transcriptome of tumor tissues from MC38 bearing mice

Project description:Transcriptome of tumor tissues from MC38 bearing mice Transcriptome

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CD45+ single cell transcriptomes in the MC38 tumor microenvironment

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Single cell TCR-seq of T cells isolated from MC38 mouse tumors

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2019-05-11 | E-MTAB-7918 | biostudies-arrayexpress

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