Biofilm on TiN and TiCN coated discs
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ABSTRACT:
PROVIDER: PRJEB45733 | ENA |
REPOSITORIES: ENA
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Project description:Surface characterization and assessment of biofilm formation on two titanium-based implant coating materials
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Project description:Titanium is a common implant material. However, in some patients titanium implants fail. Macrophages are key cells involved in foreign body response. To identify macrophage response to titainum, primary human macrophages were cultured on polished titanium discs for 6 days We used microarrays to determine the global expression pattern induced by polished titanium in macrophages and identify potential genes involved in implant failure.
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Project description:Titanium is a common implant material. However, in some patients titanium implants fail. Macrophages are key cells involved in foreign body response. To identify macrophage response to titainum, primary human macrophages were cultured on porous titanium discs for 6 days We used microarrays to determine the global expression pattern induced by porous titanium in macrophages and identify potential genes involved in implant failure.
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Project description:In this study the gene expression differences between two titanium surfaces produced at Maastricht University were investigated. These two surfaces were: flat titanium-coated polystyrene and a titanium-coated polystyrene surface imprinted with a pattern selected from an earlier screening study (Ti1018). This pattern was selected based on the osteoinductive properties observed. As a positive control cells on the flat surface were treated with dexamethasone.
2018-09-25 | E-MTAB-7212 | biostudies-arrayexpress
Project description:Hydroxyapatite (HA) coating on orthopedic implants is known to enhance osteogenesis and bone-implant integration. However its molecular basis remains to be investiagated. In this study, we performed transcriptome analysis of osteoblasts on nano-HA-coated surfaces.
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Project description:In this study the gene expression differences between three titanium surfaces produced by Straumann were investigated. These three surfaces were: flat pre-treated (Pt) titanium, sandblasted (S) titanium and sandblasted acid-etched (SLA) titanium. The SLA surface is known to boost the proliferation and osteogenic differentiation of MG-63 cells. SLA titanium is also widely used for dental implants.
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Project description:To determine the early temporal wide genome transcription regulation by the surface topography at the bone-implant interface of implants bearing micro-roughened or superimposed nanosurface topology. Fourty four cp titanium implants with surface topographies exhibiting nanoscale features (Osseospeed-OS) and microrough surface without nanoscale features (TiOblast-TiO) were placed in the alveolar bone of 11 systemically healthy subjects and subsequently harvested at 3 and 7 days after placement. Total RNA was isolated from cells adherent to retrieved implants. A whole genome microarray using the Affymetrix Human gene 1.1 ST Array was used to describe the gene expression profiles that were differentially regulated by the implant surfaces.
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Project description:In implant repair, early soft tissue healing can form a stable barrier to prevent implant loosening failure caused by bacterial invasion. The adhesion between the epithelium surrounding the implant and the surface of the titanium implant is achieved through hemidesmosomes. The connective tissue interface is composed of fibroblasts and collagen fibers with poor vascular structure and rich scar tissue like structure, which are parallel to the surface of titanium implants. In natural teeth, the collagen fibers on the surface of the dentin are vertical. The surface structure and coverage of biological factors at the neck ring of the implant are important factors affecting the soft tissue adhesion around the implant. The microgroove structure can alter the fiber pathway at the junction of the abutment and soft tissue, and regulate the phenotypic transformation of macrophages; Concentrated growth factor (CGF) derived from blood can promote the healing of gingival soft tissue after surgery and regulate immune response. However, the combined effect of microgrooves and CGF has not been studied yet. We use femtosecond laser to etch micro grooves on the neck ring of the implant, and infiltrate CGF into the neck ring of the implant micro groove through immersion, so that the micro groove structure works in combination with CGF. The implant is implanted into the alveolar bone of beagle dogs, and the color, shape, texture, and gingival margin position of the gingiva are checked for relevant clinical data measurement. Then, the implant is harvested together with the surrounding soft and hard tissues to preserve the ability of soft tissue attachment and recognition of biological width, for histological preparation and analysis. This study delves into the phenomenon of promoting implant transgingival integration, anchoring collagen fibers vertically, and making connective tissue adhesion more stable and firm, as well as its immune regulatory mechanism. This study constructed an implant with a micro groove neck ring and concentrated growth factor (CGF) derived from blood, clarifying the relationship between the binding of the micro groove structure in the neck of the implant and the sealing effect of the connective tissue around the implant. It revealed that the micro groove structure and CGF can promote M2 polarization of macrophages in the gingival connective tissue, and clarified that the morphology of the micro groove in the neck of the implant combined with CGF can promote the phenomenon of implant transgingival binding.
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