Project description:Progressive retinal atrophy (PRA) is a common cause of blindness in many pure and mixed breed dogs (Canis lupus familiaris). The typical onset of PRA begins with gradual night vision loss followed by day vision loss due to the death of rod and cone receptors, respectively. There are currently no mutations or genes reported to be causative or associated with PRA in the Hungarian Puli. In this study, we use an extensive list of 53 known PRA genes to screen for putative causal variants in this breed of dog.
Project description:Viromes of sour and sweet cherry trees in Hungarian germ line collections were surveyed using small RNA HTS as an unbiased method. RNA from leaf samples of different cultivars were purified and used to produce seven pools from which small RNA HTS libraries were prepared. The sequenced reads were analyzed using bioinformatic methods to revel the presence of viruses in the samples. Presence of the viruses were validated using RT-PCR.
Project description:Here we derive candidate gene-environment interaction (GxE) variants from promoter-enhancer interacting regions that respond to dietary fatty acid challenge through altered chromatin accessibility in human primary adipocytes, and demonstrate that molecular genomics data produced in physiologically relevant contexts can illuminate new functional GxE mechanisms in humans and identify variants for GxE testing in large biobanks.
Project description:The testicular tissue of Hungarian White Goose was selected from three stages of the laying cycle (initial, peak and end stages), and the DIA strategy was used for proteomic sequencing.
Project description:Hungarian Tokaji "aszu" and "furmint" wines were analyzed by LC-MS/MS in order to identify the molecular composition of the wines and to found compounds with potential health benefits.