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Tracing the emergence of primordial germ cells from bilaminar disc rabbit embryos and pluripotent stem cells (cell culture)

ABSTRACT: Tracing the emergence of primordial germ cells from bilaminar disc rabbit embryos and pluripotent stem cells (cell culture)

PROVIDER: PRJEB47627 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR6787300_1.fastq.gz	Fastqsanger.gz
	ERR6787300_2.fastq.gz	Fastqsanger.gz
	ERR6787310_1.fastq.gz	Fastqsanger.gz
	ERR6787310_2.fastq.gz	Fastqsanger.gz
	ERR6787320_1.fastq.gz	Fastqsanger.gz

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Tracing the emergence of primordial germ cells from bilaminar disc rabbit embryos and pluripotent stem cells (cell culture)

Project description:Rabbit embryos, as in humans, develop as bilaminar discs at gastrulation and unlike egg cylinders as in rodents. Mammalian primordial germ cells (PGCs) in all species originate during gastrulation. We sequence the transcriptomes of rabbit embryos during gastrulation, and show that rabbit PGC (rbPGC) specification occurs at the posterior epiblast at the onset of gastrulation

2021-10-14 | E-MTAB-10893 | biostudies-arrayexpress

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Tracing the emergence of primordial germ cells from bilaminar disc rabbit embryos and pluripotent stem cells (bulk RNA-sequencing)

Project description:Tracing the emergence of primordial germ cells from bilaminar disc rabbit embryos and pluripotent stem cells (bulk RNA-sequencing)

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Effect of an Analgesic Drug on Necelus Pulposus Cells from Human Intervertebral Disc (IVD) Tissues

Project description:Neurotropin (NTP), a non-protein extract from inflamed rabbit skin inoculated with vaccinia virus. It has been widely used in Japan to treat low back pain. The current sutudy evaluated its stimulative effect on the disc cells to enhance glycosaminoglycan synthesis, which is one of the most important functions of the cells. Gene expression profile was exzamined in the cells treated with or without NTP in vitro.

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Comparison of human primordial oocyte follicles to ovarian somatic cells

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A temporally resolved BMP4 response in the peri-implantation human embryonic disc is critical for the induction of multipotent TFAP2A + cells and EMT

Project description:The unilaminar embryonic disc, a sheet of epithelized SOX2+ epiblast cells, undergoes complex morphogenesis to create a multi-dimensional human gastrula. This process endows early lineage specification and spatial identities that begin at the posterior end of the disc to create a coordinate system for embryogenesis. Here, we find that simply adding basement membrane extracts (BMEs) to the stem cell media is sufficient to model the early peri-gastrulating embryonic disc. We demonstrate that the emergence of amnion, primordial germ cells (PGCs), and mesoderm arise from BMP4-responsive disc cells that induce transient TFAP2A expression and SOX2 repression. We track the order of embryonic events that take place during disc morphogenesis and show that amnion-like cells (AMLCs) and PGC-like cells (PGCLCs) are specified first from epithelized TFAP2A+ progenitors. Shortly after, gastrulating mesoderm-like cells (MeLCs) arise from transiently expressed TFAP2A+ disc cells that then undergo EMT. We find that BMP4-responsiveness is critical to SOX2 repression, TFAP2A expression, lineage induction and EMT, while the process of EMT itself is not. Thus, we show that the extracellular matrix is necessary to promote disc morphogenesis and EMT.

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Project description:Intervertebral disc degeneration

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