Brain-RNA-Seq
Ontology highlight
ABSTRACT:
PROVIDER: PRJEB52665 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:RNA-Seq from liver of Large White immunocastrated male fed with different oils
| PRJEB50513 | ENA
Project description:RNA-Seq from skeletal muscle of Large White immunocastrated male fed with different oils
| PRJEB52629 | ENA
Project description:Profile the expression of micoRNAs in the human brain at prenatal, early childhood, and adult timepoints 37 prenatal cerebral tissue samples, 11 postnatal cerebral tissue samples, 2 adult total brain samples (FirstChoice Human Brain Reference RNA cat# AM6050 and FirstChoice Human Brain Total RNA cat# AM7962*. *The current FirstChoice Human Brain Total RNA (2013), is from a 78 year old white female, while the FirstChoice Total RNA used in this deposited data set was from an 81 year old white male, which is no longer available through Ambion/Life Technologies.)
2013-03-21 | E-GEOD-45126 | biostudies-arrayexpress
Project description:Vanishing white matter (VWM) is a leukodystrophy that primarily manifests in young children. In this disease, the brain white matter is differentially affected in a predictable pattern with telencephalic brain areas being more severely affected, while others remain allegedly completely spared. Using high-resolution mass spectrometry-based proteomics, we investigated the proteome patterns of the severely affected white matter in the frontal lobe and normal appearing pons in VWM and control cases to identify molecular bases underlying regional vulnerability. By comparing VWM patients to controls, we identified disease-specific proteome patterns. We showed substantial pathogenic changes in both the frontal white matter and pons at the protein level. Side-by-side comparison of brain region-specific proteome patterns further revealed regional differences. We found that different cell types are affected in the VWM frontal white matter than in the pons. Gene ontology and pathway analyses identified involvement of region distinct biological processes, of which pathways implicated in cellular respiratory metabolism were overarching features. In the VWM frontal white matter, proteome changes were associated with decrease in glycolysis/gluconeogenesis and metabolism of various amino acids. By contrast, in the VWM pons white matter, we found a decrease in oxidative phosphorylation. Taken together, our data show that brain regions are affected in parallel in VWM, but to different degrees. We found region-specific involvement of different cell types and discovered that cellular respiratory metabolism is differently affected across white matter regions in VWM. These region-specific changes help explain regional vulnerability to pathology in VWM.
2023-06-28 | PXD040861 | Pride
Project description:We report differential expressed genes in white and brown adipose tissues with surgical denervation procedure in male mice fed with a high-fat diet.
2019-02-16 | GSE126652 | GEO
Project description:We report differential expressed genes in white and brown adipose tissues with surgical denervation procedure in male mice fed with a low-fat diet.
2019-02-16 | GSE126649 | GEO
Project description:Mice were fed black rice, white brown rice and polish rice to compare the effects of different diets on ovarian aging
2025-05-18 | GSE235021 | GEO
Project description:RNA-Seq analysis carried out in three different backcrosses based on Iberian breed with Landrace, Pietrain and Duroc breeds
2017-10-31 | PRJEB23068 | EVA
Project description:Purpose: To investigate the effect that acute ethanol tretament (5 g/kg) has on the brain transcriptome and relate that to ethanol-related behaviors. Methods: Male LXS recombinant inbred mice (40 strains; n=2 or 3 per strain) were treated with saline or ethanol (i.p.; 5 g/kg). Paired-end RNA-seq methods were employed to assess mRNA expression in whole brain 8 hours after the treatment. Results: The expression of thousands of transcripts was altered by the ethanol treatment. Thousands of expression QTLs (eQTLs) were mapped. A large percentage of the eQTLs were unique to the treatment.
2020-10-28 | GSE157215 | GEO
Project description:Diet is a potentially modifiable neurodegenerative disease risk factor. We studied the effects of a typical Western diet (WD) relative to a heart-healthy diet (HHD) on microvessel transcriptomics and metabolomics of the brain temporal region in Ossabaw minipigs. Thirty-two pigs (16 male and 16 females) were randomized to the WD or HHD starting at the age of 4 months and were fed the assigned diet for the following 6 months. The WD and HHD were isocaloric and had the same macronutrient content but differed in macronutrient quality. Within each dietary group, half of the pigs also received a statin. Relative to HHD-fed pigs, WD-fed pigs had 2,172 genes differentially expressed (FDR<0.05) by diet, 796 upregulated and 1,376 downregulated. Gene Set Enrichment Analysis identified 22 gene sets enriched in WD, comprising pathways related to inflammation, angiogenesis, and apoptosis, and 53 gene sets enriched in the HHD, including cell energetics, neurotransmission, and inflammation resolution pathways. Enrichment in arginine, tyrosine, and lysine was observed in WD-fed pigs and enrichment in ergothioneine and S-adenosyl methionine in HHD-fed pigs. Statin treatment had very modest effects on brain vessel transcriptome. Our study suggests a likely contribution of diet to brain pathologies characterized by neuroinflammation and neurodegeneration.
2025-01-06 | GSE263935 | GEO