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PROVIDER: PRJEB54984 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Hungarian white goose BMP4 gene exon 6, TGFb3 gene exon 6, Msx2 gene exon 1 and 2 SNP detection.
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Project description:The testicular tissue of Hungarian White Goose was selected from three stages of the laying cycle (initial, peak and end stages), and the DIA strategy was used for proteomic sequencing.
2024-04-03 | PXD051163 |
Project description:The homeoprotein Msx1 and Msx2 involved in normal skeletal muscle development and also contribute to muscle defects if altered during development. Deciphering the downstream signaling networks of Msx1 and Msx2 in myoblasts differentiation will help us to understand the molecular events that contribute to muscle defects. The objective of this study was to evaluate the proteomics characteristics in Msx1 and Msx2 mediated myoblasts differentiation, using isobaric tags for the relative and absolute quantification labelling technique (iTRAQ). The results showed that 1535 proteins with quantitative information were obtained. Volcano plots illustrated, in undifferentiated stage, 32 common downstream regulatory proteins for Msx1 and Msx2, 39 specific regulatory proteins for Msx1, and 13 specific for Msx2. While, in differentiated stage, 17 common downstream regulatory proteins for Msx1 and Msx2, 10 specific regulatory proteins for Msx1, and 21 specific for Msx2. Gene ontology, KEGG pathway and protein-protein interaction networks analyses revealed these proteins primarily associated with Arginine and proline metabolism, Glycolysis/Gluconeogenesis, Fatty acid degradation, Metabolism of xenobiotics by cytochrome P450 and Apoptosis. In addition, our data shows Acta1 was probably a core of the downstream regulatory networks of Msx1 and Msx2 in skeletal muscle development. The findings will help us to understand the molecular roles of Msx1 and Msx2 during muscle development as well as regeneration, and to understand the molecular events that contribute to muscle defects.
2023-07-20 | PXD026944 | Pride
Project description:The unique fat storage and metabolic characteristics of goose liver is an important model for studying lipid metabolism in animals or humans. In this study, RNA sequencing technology was used to obtain the liver transcriptome of Sichuan white goose with significant weight difference in the same population, and differentially expressed genes and their pathways were identified, which may help to understand the mechanism of goose weight change. In addition, the identified candidate genes may be useful for molecular breeding of geese.
2020-02-28 | GSE132921 | GEO
Project description:Purpose: To understand the function differences of goose at broody and breeding stage Methods: RNA-seq analysis of oviduct tissues in reproductive and broody goose Results: Our study screened differential expressed mRNA and pathways involved in broodiness Conclusions:The differential expressed mRNA and pathways identified in this study may contribute to understand the broodiness occurs in goose
2019-04-25 | GSE130245 | GEO
Project description:The thymus is essential for T cell development and the establishment of central tolerance, yet avian thymic development remains poorly characterized. Using the Zhedong White goose as a model, we analyzed thymic development across four stagesby integrating histological analysis with single-cell RNA sequencing. The goose thymus exhibits a multilobulated architecture, undergoes rapid post-hatch maturation, and shows stage-dependent involution. Single-cell analysis identified the major thymic cell populations, with T cells predominating and γδ T cells present at higher proportions than in mammals. Pseudotime analysis revealed double-positive (DP) cells as a central differentiation hub. Double-negative (DN) thymocytes progressed from DN1 to DN3b through a stepwise program characterized by lineage commitment marked by upregulation of BCL11B, NOTCH1, and TCF7, followed by induction of β-selection–associated genes, including RAG1/2 and DNTT. Thymic epithelial cells functioned as a major signaling hub, with adhesion- and microenvironment-related pathways coordinating TEC–T cell interactions, while DP and mature T cells progressively emerged as key signal integration nodes. Cross-species comparison indicated an overall conserved developmental framework, with the most pronounced species-specific differences observed at the DP stage. Collectively, this study systematically delineates the developmental trajectories of thymic T cells and their microenvironmental regulation in the goose, providing a valuable resource for studies of avian immune development and comparative immunology.
2026-02-28 | GSE315444 | GEO