Project description:In deceased donor kidney transplantation, acute kidney injury (AKI) prioir to surgery is a major determinant of delayed graft function (DGF), but AKI is histologically silent and difficult to assess. We hypothesized that a molecular measurement of AKI would add power to conventional risk assessments to predict the early poor allograft function at first week post transplantation.
Project description:High throughput transcriptomics using the TempO-Seq (TM) platform for dose response modelling of 3 different cell lines treated with the compound Benzophenone-4 as part of case study to explore the application of Next Generation Risk Assessment approaches for a sunscreen active ingredient. The data generated here was produced as one part of a toolbox of technologies to inform on bioactivity.