Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Single cell RNA-seq of perinatal mouse hematopoietic stem cells

ABSTRACT: Single cell RNA-seq of perinatal mouse hematopoietic stem cells

PROVIDER: PRJEB65353 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ERR11881274_1.fastq.gz	Fastqsanger.gz
	ERR11881274_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 2 of 2

Similar Datasets

Single cell RNA-seq of perinatal mouse hematopoietic stem cells

Project description:Molecular characterization of perinatal liver HSCs.

2023-09-30 | E-MTAB-13293 | biostudies-arrayexpress

single cell RNA sequencing of transplanted mouse hematopoietic stem cells

Project description:single cell RNA sequencing of transplanted mouse hematopoietic stem cells

| PRJNA678712 | ENA

Hematopoietic stem cells (HSCs)

Project description:G0 marker-separation of dormant and active hematopoietic stem cells reveals dormancy regulation by basal cytoplasmic calcium

2019-12-19 | PXD012093 | JPOST Repository

single cell RNA sequencing of transplanted mouse hematopoietic stem cells

Project description:transcriptome analysis of mouse hematopoietic stem cells four months post transplantation at single cell resolution

2020-11-18 | GSE161560 | GEO

Differential requirements for Smarca5 expression during hematopoietic stem cell commitment.

Project description:The formation of hematopoietic cells relies on the chromatin remodeling activities of ISWI ATPase SMARCA5 (SNF2H) and its complexes. The Smarca5 null and conditional alleles have been used to study its functions in embryonic and organ development in mice. These mouse model phenotypes vary from embryonic lethality of constitutive knockout to less severe phenotypes observed in tissue-specific Smarca5 deletions, e.g., in the hematopoietic system. Here we show that, in a gene dosage-dependent manner, the hypomorphic allele of SMARCA5 (S5tg) can rescue not only the developmental arrest in hematopoiesis in the hCD2iCre model but also the lethal phenotypes associated with constitutive Smarca5 deletion or Vav1iCre-driven conditional knockout in hematopoietic progenitor cells. Interestingly, the latter model also provided evidence for the role of SMARCA5 expression level in hematopoietic stem cells, as the Vav1iCre S5tg animals accumulate stem and progenitor cells. Furthermore, their hematopoietic stem cells exhibited impaired lymphoid lineage entry and differentiation. This observation contrasts with the myeloid lineage which is developing without significant disturbances. Our findings indicate that animals with low expression of SMARCA5 exhibit normal embryonic development with altered lymphoid entry within the hematopoietic stem cell compartment.

2025-10-27 | PXD048865 | panorama

GNPS - Hematopoietic stem cell derived conditioned media metabolomics

Project description:Metabolomic data of conditioned media derived from culturing hematopoietic stem cells.

2025-02-14 | MSV000097113 | GNPS

Single-cell transciptional profiling of thymic hAPCs in perinatal mice

Project description:This study carried out single-cell transcriptional profiling of FACS purified thymic hematopoietic antigen presenting cells (hAPCs) to determine changes in cellular composition and gene signatures in neonatal to perinatal (P00, P03, P07, P10, and P14) mice.

2025-12-05 | GSE287039 | GEO

Expression data from mouse hematopoietic stem cells

Project description:Expression data from mouse hematopoietic stem cells

| PRJNA433254 | ENA

single cell RNA seq of mouse bone marow-derived hematopoietic stem progenitor cells

Project description:single cell RNA seq of mouse bone marow-derived hematopoietic stem progenitor cells

| PRJNA557144 | ENA