Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Supplementing L-Citrulline can extend lifespan and attenuate the development of aging related insulin resistance and intes-tinal barrier dysfunction

ABSTRACT: Supplementing L-Citrulline can extend lifespan and attenuate the development of aging related insulin resistance and intes-tinal barrier dysfunction

PROVIDER: PRJEB65871 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Xbp1 overexpression in the gut and fat body extend Drosophila lifespan

Project description:Manipulating the activity of transcription factor (TF) to regulate animal’s longevity is achieved in different species. However, deciphering the pro-longevity transcriptional programme triggered by the TFs activity is challenging. One obstacle is the multifunctional feature of TFs. The physiological functions of single TF could be diverse and tissues-dependent. The other is the gene regulatory network among the TFs, where multiple TFs can have synergetic or antagonistic impact on the same target genes. Here, we show Xbp1s overexpression in gut and fat body can extend lifespan in Drosophila. Importantly, Xbp1s activity triggers distinct transcriptional programmes in the two tissues, and Xbp1s induction in both tissues are beneficial for longevity. Furthermore, we reveal a pro-longevity gene regulatory network in the fat body, where Xbp1s and dFOXO impinge on the same target genes and induce identical transcriptional outcomes. dfoxo overexpression requires Xbp1 to extend lifespan. Lastly, inducing Xbp1u, the precursor of Xbp1s, can also extend lifespan without triggering massive transcriptome change.

2024-05-06 | GSE246232 | GEO

Combining Stem Cell Rejuvenation and Senescence Targeting to Synergistically Extend Lifespan

Project description:Combining Stem Cell Rejuvenation and Senescence Targeting to Synergistically Extend Lifespan

| PRJNA830891 | ENA

Xbp1 overexpression in the gut and fat body extend Drosophila lifespan

Project description:Xbp1 overexpression in the gut and fat body extend Drosophila lifespan

| PRJNA1032092 | ENA

Reduced circulating insulin enhances insulin sensitivity in old mice and extends lifespan

Project description:The causal relationships between insulin levels, insulin resistance, and longevity are not fully elucidated. Genetic down-regulation of insulin/insulin-like growth factor 1 (Igf1) signaling components can extend invertebrate and mammalian lifespan, but insulin resistance, a natural form of decreased insulin signaling, is associated with greater risk of age-related disease in mammals. We compared Ins2+/- mice to Ins2+/+ littermate controls, on a genetically stable Ins1-null background. Proteomic and transcriptomic analyses of livers from 25 week-old mice suggested potential for healthier aging and altered insulin sensitivity in Ins2+/- mice. Halving Ins2 lowered circulating insulin by 25-34% in aged female mice, without altering Igf1 or circulating Igf1. Remarkably, decreased insulin led to lower fasting glucose and improved insulin sensitivity in aged mice. Moreover, lowered insulin caused significant lifespan extension, observed across two diverse diets. Our study indicates that elevated insulin contributes to age-dependent insulin resistance, and that limiting basal insulin levels can extend lifespan.

2017-07-07 | PXD006613 | Pride

Reduced circulating insulin enhances insulin sensitivity in old mice and extends lifespan

2017-05-31 | GSE99440 | GEO

Glycation-lowering compounds inhibit ghrelin signaling to reduce food intake, lower insulin resistance, and extend lifespan.

Project description:Glycation-lowering compounds inhibit ghrelin signaling to reduce food intake, lower insulin resistance, and extend lifespan.

| PRJNA981518 | ENA

Engineering ATP Import in Yeast Uncovers a Synthetic Route to Extend Cellular Lifespan

Project description:Engineering ATP Import in Yeast Uncovers a Synthetic Route to Extend Cellular Lifespan

| PRJNA1377588 | ENA

The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan

Project description:The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan

| PRJNA1219486 | ENA

Protein chaperones elicit a caloric restriction-like response to extend replicative lifespan

Project description:The involvement of protein chaperones in aging is intriguing and their potential contribution has, so far, been attributed solely to their central role in proteostasis. Here we show that four protein chaperones from different cellular compartments extend replicative lifespan (RLS) in budding yeast by a common mechanism akin to caloric restriction. The RLS extension relies on the increased direct activation of Snf1 kinase by Hsp90, thereby bypassing the signal on the environmental glucose level. The chaperone-related RLS extension is accompanied by the uncoupling of the respiratory chain. A genomic approach confirmed the repression of glycolysis and cytoplasmic translation, and contrary, activation of gluconeogenesis and fatty acid oxidation. Our results set a novel paradigm for the role of protein chaperones: by modulation of the chaperone expression level one can affect metabolic features such as glucose sensing, fatty acid consumption, respiration rate, and, consequently, modify lifespan. We expect the described mechanism to open new avenues for research in aging and age-related diseases.

2017-06-28 | GSE71711 | GEO

Mitochondrial stress activates ELT-2-dependent lysosomal proteostasis to extend lifespan in C. elegans

Project description:Mitochondrial stress activates ELT-2-dependent lysosomal proteostasis to extend lifespan in C. elegans

| PRJNA1252052 | ENA