Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA-Seq analysis of healthy volunteers that are dengue seronegative or seropositive

ABSTRACT: RNA-Seq analysis of healthy volunteers that are dengue seronegative or seropositive

PROVIDER: PRJEB67470 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

RNA-Seq analysis of healthy volunteers that are dengue seronegative or seropositive

Project description:RNA was extracted from whole blood of subjects collected in Tempus tubes. We performed gene expression analysis of dengue seropositive versus dengue seronegative subjects.

2025-09-08 | E-MTAB-13429 | biostudies-arrayexpress

Microarray analysis of dengue seronegative or seropositive volunteers that received the tetravalent dengue vaccine TAK-003

Project description:Samples were collected from the DEN210 study, a phase IIb clinical trial evaluating two doses of TAK003, a tetravalent dengue vaccine, administered 90 days apart in healthy adult participants with and without prior DENV infection (NCT03746015). RNA was extracted from whole blood collected in Paxgene tubes from volunteers at Day 1, 4, 6, 90, 94 and 96. Day 1 and Day 90 samples were collected prior to administration of first and second TAK-003 vaccine dose. We performed gene expression analysis in dengue seronegative and seropositive individuals over time.

2025-09-08 | E-MTAB-13470 | biostudies-arrayexpress

RNA-seq for dengue seronegative and dengue seropositive individuals from Singapore

Project description:RNA was extracted from whole blood of subjects collected in Tempus tubes. We performed gene expression analysis of dengue seropositive versus dengue seronegative subjects from Singapore.

2025-09-08 | E-MTAB-14343 | biostudies-arrayexpress

Single cell RNA-Seq of dengue seronegative and seropositive individuals

Project description:Single cell RNA-seq was conducted on peripheral blood mononuclear cells (PBMCs) collected from study participants that were dengue seronegative (n=3) or dengue seropositive (n=3). Baseline single cell gene expression profiling was conducted using 10x Genomics Chromium Next GEM Single Cell 3’ Reagent Kits v3.1 (Dual Index).

2025-09-08 | E-MTAB-13441 | biostudies-arrayexpress

RNA-seq for dengue seronegative and dengue seropositive individuals from Singapore

Project description:RNA-seq for dengue seronegative and dengue seropositive individuals from Singapore

| PRJEB78835 | ENA

Single cell RNA-Seq of dengue seronegative and seropositive individuals

Project description:Single cell RNA-Seq of dengue seronegative and seropositive individuals

| PRJEB67536 | ENA

Immune transcriptomes of highly exposed SARS-CoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community

Project description:SARS-CoV-2 infection ranges from asymptomatic to severe with lingering symptomatology in some. This prompted investigation of whether or not asymptomatic disease results in measurable immune activation post-infection. Immune activation following asymptomatic SARS-CoV-2 infection was characterized through a comparative investigation of the immune cell transcriptomes from 43 asymptomatic seropositive and 52 highly exposed seronegative individuals from the same community four to six weeks following a superspreading event. Few of the 95 individuals had underlying health issues. One seropositive individual reported Cystic Fibrosis and one individual reported Incontinentia pigmenti. No evidence of immune activation was found in asymptomatic seropositive individuals with the exception of the Cystic Fibrosis patient. There were no statistically significant differences in immune transcriptomes between asymptomatic seropositive and highly exposed seronegative individuals. Four positive controls, mildly symptomatic seropositive individuals whose blood was examined three weeks following infection, showed immune activation. Negative controls were four seronegative individuals from neighboring communities without COVID19. All individuals remained in their usual state of health through a five-month follow-up after sample collection. In summary, whole blood transcriptomes identified individual immune profiles within a community population and showed that asymptomatic infection within a super-spreading event was not associated with enduring immunological activation.

2021-05-01 | GSE162562 | GEO

Nicaragua Dengue Natural Infection

Project description:These 40 microarray datasets represent whole blood samples from 31 primary dengue infection patients and 9 healthy volunteers from Managua, Nicaragua. The dengue infection patients include both primary dengue fever (DF) and primary dengue hemorrhagic fever (DHF) cases.

2018-07-31 | GSE96656 | GEO

RNA seq analysis of human monocyte subsets in healthy and dengue subjects

Project description:In this analysis, sorted classical (CM), intermediate (IM) and non-classical (NCM) monocyte subsets from children under steady state (healthy, H) and dengue febrile illness (Dengue, D) were analyzed for their transcriptional profiles using RNA seq. The monocyte subsets were sorted from peripheral blood cells after excluding CD3, CD19, CD20, CD56, CD66b and NKp30 positive cells and then gating on HLADR positive population to identify CM, IM and NCM subsets based on surface expression of CD16 and CD14. The transcriptional profile of the three monocyte subsets was separately compared in healthy children, in dengue febrile children and in dengue versus healthy states. This study highlights hierarchy of gene expression in classical, intermediate and non-classical monocytes in healthy and dengue febrile conditions.

2022-05-16 | GSE176079 | GEO

Differential miRNome analysis in a dengue resistant cohort versus susceptible after Dengue Virus serotype 2 or mock in vitro infection

Project description:MicroRNAs have emerged as relevant players in resistance to infection. We aimed to identify miRNAs involved in natural resistance to dengue infection. Two groups of people living in dengue endemic area were classified as susceptible (SD) or resistant (RD) to dengue virus (DENV) infection according to their anti-DENV antibody status. We hypothesized that anti-DENV seronegative individuals may represent a population resistant to DENV infection. The miRNome from monocytes of 7 individuals of each group was assessed upon mock- or DENV-2 infection.Dysregulated miRNAs were chosen as candidates for functional studies.

2025-02-12 | E-MTAB-13628 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data