Dataset Information

Transcriptomes of subterranean mammals reveal that naked mole rats have distinctive cardiometabolic and genetic adaptations to their underground low-oxygen lifestyles

ABSTRACT: Transcriptomes of subterranean mammals reveal that naked mole rats have distinctive cardiometabolic and genetic adaptations to their underground low-oxygen lifestyles

PROVIDER: PRJEB72773 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Dataset's files

Source:

			Action	DRS
		Other
	ERR12667300_1.fastq.gz	Fastqsanger.gz
	ERR12667300_2.fastq.gz	Fastqsanger.gz
	ERR12667301_1.fastq.gz	Fastqsanger.gz
	ERR12667301_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 91

Similar Datasets

Project description:BackgroundNaked mole-rats (Heterocephalus glaber, NMRs) and blind mole-rats (Spalax galili, BMRs) are representative subterranean rodents that have evolved many extraordinary traits, including hypoxia tolerance, longevity, and cancer resistance. Although multiple candidate loci responsible for these traits have been uncovered by genomic studies, many of them are limited to functional changes to amino acid sequence and little is known about the contributions of other genetic events. To address this issue, we focused on gene losses (unitary pseudogenes) and systematically analyzed gene losses in NMRs and BMRs, aiming to elucidate the potential roles of pseudogenes in their adaptation to subterranean lifestyle.ResultsWe obtained the pseudogene repertoires in NMRs and BMRs, as well as their respective aboveground relatives, guinea pigs and rats, on a genome-wide scale. As a result, 167, 139, 341, and 112 pseudogenes were identified in NMRs, BMRs, guinea pigs, and rats, respectively. Functional enrichment analysis identified 4 shared and 2 species-specific enriched functional groups (EFGs) in subterranean lineages. Notably, the pseudogenes in these EFGs might be associated with either regressive (e.g., visual system) or adaptive (e.g., altered DNA damage response) traits. In addition, several pseudogenes including TNNI3K and PDE5A might be associated with specific cardiac features observed in subterranean lineages. Interestingly, we observed 20 convergent gene losses in NMRs and BMRs. Given that the functional investigations of these genes are generally scarce, we provided functional evidence that independent loss of TRIM17 in NMRs and BMRs might be beneficial for neuronal survival under hypoxia, supporting the positive role of eliminating TRIM17 function in hypoxia adaptation. Our results also suggested that pseudogenes, together with positively selected genes, reinforced subterranean adaptations cooperatively.ConclusionsOur study provides new insights into the molecular underpinnings of subterranean adaptations and highlights the importance of gene losses in mammalian evolution.

Dataset Information

Transcriptomes of subterranean mammals reveal that naked mole rats have distinctive cardiometabolic and genetic adaptations to their underground low-oxygen lifestyles

Dataset's files

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets