Project description:The proteomes of the nitrogen-fixin bacterium Frankia alni, the tree Alnus glutinosa (Alder), and the oomycete plant pathogen Phytophthora alni were established by shotgun proteomics in specific conditions to assess Alnus glutinosa responsiveness to Phytophthora alni infection in presence of Frankia alni.
Project description:The proteomics analysis of the nitrogen-fixin bacterium Frankia alni, the tree Alnus glutinosa (Alder), and the oomycete plant pathogen Phytophthora alni was carried out by shotgun proteomics from nodules to establish the defence mechanisms of the symbiont during an infection.
Project description:Considering that dysregulation of cholesterol levels has been established as one of the hallmarks of cancer, moreover ferroptosis, autophagy, tumor cell, immune cell stemness, and the cellular DNA damage response are regulated through cholesterol metabolism, while recent research studies have shown that dietary supplementation with sea buckthorn reduced total cholesterol only in people with abnormal lipid metabolism, the aim of this study was to identify, for the first time, the main signaling pathways, biological processes, cellular functions, and upstream regulators modulated by lipophilic sea buckthorn extract (LSBE) in BT-549 TNBC cell line.