Project description:Cd1 wildetype mice, Wt1-CreER;Rosa-mTmG mice, and Wt1-CreER;Rosa-DTA mice derived hearts were isolated and directly embeded. The hearts were then sectioned for spatial transcriptomic analysis.

2026-04-28 | GSE282547 | GEO

Bathyraja spinosissima

Project description:Bathyraja spinosissima overview

| PRJNA1374551 | ENA

Effect of Rosa roxburghii fruit extracts to gene expression of mesenchymal stem cells

Project description:Here we found Rosa roxburghii fruit extracts effectively increase TERT expression and telomerase activity in cultured human mesenchymal stem cells. Both Rosa roxburghii fruit extracts by freeze drying and spray drying methods increase the activity of telomerase. Rosa roxburghii fruit freeze drying extracts is able to reduce reactive oxygen species levels, enhance SOD activity and resistance to oxidative stress, and reduce DNA damage caused by oxidative stress or radiation. Rosa roxburghii fruit extracts promoted cell proliferation, improved senescent cell morphology, delayed replicative cellular senescence, attenuated cell cycle supressors and alleviated the senescence-associated secretory phenotype. Transcriptome and metabolic profilings found that Rosa roxburghii fruit extract promote cell proliferation and DNA repair pathways, decreased triglycerides as well. Overall, we provided a theoretical basis for the application of Rosa roxburghii fruit as an anti-aging natural product.

2024-04-01 | GSE261987 | GEO

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