Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Recombination processes inferred from long-read sequencing of primate testis and human sperm

ABSTRACT: Recombination processes inferred from long-read sequencing of primate testis and human sperm

PROVIDER: PRJEB77177 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other
	ERR14376317.fastq.gz	Fastqsanger.gz
	ERR14376418.fastq.gz	Fastqsanger.gz
	ERR14368733.fastq.gz	Fastqsanger.gz
	ERR14376437.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 11

Similar Datasets

Insights into non-crossover recombination from long-read sperm sequencing.

Project description:Meiotic recombination is a fundamental process that generates genetic diversity by creating new combinations of existing alleles. Although human crossovers have been studied at the pedigree, population and single-cell level, the more frequent non-crossover events that lead to gene conversion are harder to study, particularly at the individual level. Here we show that single high-fidelity long sequencing reads from sperm can capture both crossovers and non-crossovers, allowing effectively arbitrary sample sizes for analysis from one male. Using fifteen sperm samples from thirteen donors we demonstrate variation between and within donors for the rates of different types of recombination. Intriguingly, we observe a tendency for non-crossover gene conversions to occur upstream of nearby PRDM9 binding sites, whereas crossover locations have a slight downstream bias. We further provide evidence for two distinct non-crossover processes. One gives rise to the vast majority of non-crossovers with mean conversion tract length under 50bp, which we suggest is an outcome of standard PRDM9-induced meiotic recombination. In contrast ~2% of non-crossovers have much longer mean tract length, and potentially originate from the same process as complex events with more than two haplotype switches, which is not associated with PRDM9 binding sites and is also seen in somatic cells.

| S-EPMC11245106 | biostudies-literature

Extended Primate aCGH

Project description:Extended Primate aCGH

| PRJNA102527 | ENA

Primate Comparison Study

Project description:Primate Comparison Study

| PRJNA91975 | ENA

Primate malaria sequencing

Project description:Primate malaria sequencing

| PRJEB2081 | ENA

Extended Primate aCGH

Project description:This set includes individuals from 10 different primate species whose genomic DNA was used in an array-based comparative genomic hybridization (aCGH)using human cDNA microarrays to detect gene copy number variation across 10 primate species. An organism part comparison experiment design type compares tissues, regions, organs within or between organisms. Keywords: organism_part_comparison_design, array CGH Computed

2012-02-24 | E-GEOD-9028 | biostudies-arrayexpress

primate metagenome

Project description:Comparative Analysis of Primate Vaginal Microbiome

| PRJNA242706 | ENA

Extended Primate aCGH

2012-02-24 | GSE9028 | GEO

primate metagenome

Project description:Primate armpit metagenome 16S rRNA targeted loci

| PRJNA281417 | ENA

primate

Project description:genome sequencing and assembly of primate species Genome sequencing and assembly

| PRJNA785018 | ENA

Gene expression in primate postnatal brain through lifespan

Project description:This SuperSeries is composed of the following subset Series: GSE22521: Gene expression in primate postnatal brain through lifespan - prefrontal cortex GSE22569: Gene expression in primate postnatal brain through lifespan - cerebellar cortex Refer to individual Series

2011-12-09 | E-GEOD-22570 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data