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GfCliPrun

ABSTRACT: Clitopilus prunulus (the miller)

PROVIDER: PRJEB79543 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR13660011.fastq.gz	Fastqsanger.gz
	ERR13669993_1.fastq.gz	Fastqsanger.gz
	ERR13669993_2.fastq.gz	Fastqsanger.gz
	ERR13669994_1.fastq.gz	Fastqsanger.gz
	ERR13669994_2.fastq.gz	Fastqsanger.gz

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gfCliPrun

Project description:Clitopilus prunulus (the miller), genomic and transcriptomic data

| PRJEB79542 | ENA

Spatial immunophenotypes orchestrate prognosis in triple negative breast cancer with Miller Payne grade 4

Project description:Some triple-negative breast cancer (TNBC) patients evaluated as Miller-Payne 4 with ypN0 after neoadjuvant chemotherapy (NACT) who have better prognosis should avoid escalation of therapy. We aim to identify these patients through evaluating pretherapeutic spatial distributions of immunophenotypes. Our retrospective study in patients with TNBC assessed as Miller-Payne grade 4/5 with ypN0 showed that Miller-Payne 4 with ypN0 group had poorer 5-year disease-free survival (DFS, 63.8% vs 83.0%, p=0.003) and the 5-year overall survival (OS, 71.0% vs 85.5%, p=0.007) than Miller-Payne 5 with ypN0 group. High TILs were significantly associated with better DFS and OS in patients with Miller-Payne 4 and ypN0 (both p=0.016). Spatially, detected by multiplexed ion beam imaging by time of flight combined with proteomics, tumors assessed as Miller-Payne 4 and ypN0 with good prognosis exhibited an inflamed phenotype, with dominant CD8+ T cells on tumor center, few scattered CD68+ myeloid-derived cells far away from T cells, and deposit of increased activated molecules of lymphocyte. While those with poor prognosis presented excluded phenotype, with few CD8+ T cells restricted to invasive margin and a high density of CD14+CD68+CD11c+ myeloid cells. A good classifier model based on 29 spatial immunophenotypes was established by the random forest algorithm (AUC=0.975), for identifying patients with Miller-Payne 4 and ypN0 who had favorable prognosis. We also observed similar signatures in patients with Miller-Payne 5 and ypN0. Taken together, spatial immunophenotypes may assess the prognosis in TNBC patients with Miller-Payne 4 and ypN0 after NACT.

2023-07-08 | PXD029186 | Pride

Clitopilus hobsonii

Project description:Clitopilus hobsonii overview

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Clitopilus prunulus

Project description:Clitopilus prunulus overview

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Project description:Genomic insights into Clitopilus fungi

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Clitopilus hobsonii

Project description:Clitopilus hobsonii Raw sequence reads

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ilAcrLepo

Project description:Acronicta leporina (the miller)

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Clitopilus hobsonii strain:QYL-10

Project description:Clitopilus hobsonii strain:QYL-10 Genome sequencing

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Project description:Transcription of Clitopilus hobsonii -Liquidambar styraciflua interaction

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Response of ethanologenic E coli strains LY180 and EMFR9 to furfural

Project description:The data explore the transcriptional response of strain LY180 and the furfural-resistant derivative EMFR9 to 0.5 g/L furfural LY180 and EMFR9 and differences in their expression profiles are described in Miller, E. N., L. R. Jarboe, L. P. Yomano, S. W. York, K. T. Shanmugam, and L. O. Ingram. 2009. Silencing of NADPH-dependent oxidoreductase genes (yqhD and dkgA) in furfural-resistant ethanologenic Escherichia coli. Appl Environ Microbiol 75:4315-23. The response of LY180 to furfural is described in Miller, E. N., L. R. Jarboe, P. C. Turner, P. Pharkya, L. P. Yomano, S. W. York, D. Nunn, K. T. Shanmugam, and L. O. Ingram. 2009. Furfural Inhibits Growth by Limiting Sulfur Assimilation in Ethanologenic Escherichia coli strain LY180. Appl Environ Microbiol., 2009.

2009-08-25 | GSE17786 | GEO

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