3D'omics: experiment J
Ontology highlight
ABSTRACT:
PROVIDER: PRJEB86261 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:3D'omics: Adenovirus challenge poultry trial
| PRJEB86255 | ENA
Project description:3D'omics: Salmonella challenge chicken trial
| PRJEB86258 | ENA
Project description:3D'omics: Histomonas challenge turkey trial
| PRJEB86259 | ENA
Project description:3D'omics: Histomonas challenge chicken trial
| PRJEB86260 | ENA
Project description:3D'omics: protein efficiency pig trial
| PRJEB86262 | ENA
Project description:Beneficial modulation of the gut microbiome has high-impact implications not only in humans, but also in livestock that sustain our current societal needs. In this context, we have engineered an acetylated galactoglucomannan (AcGGM) fibre from spruce trees to match unique enzymatic capabilities of Roseburia and Faecalibacterium species, both renowned butyrate-producing gut commensals. The accuracy of AcGGM was tested in an applied pig feeding trial, which resolved 355 metagenome-assembled genomes together with quantitative metaproteomes. In AcGGM-fed pigs, both target populations differentially expressed AcGGM-specific polysaccharide utilization loci, including novel, mannan-specific esterases that are critical to its deconstruction. We additionally observed a “butterfly effect”, whereby numerous metabolic changes and interdependent cross-feeding pathways were detected in neighboring non-mannolytic populations that produce short-chain fatty acids. Our findings show that intricate structural features and acetylation patterns of dietary fibre can be customized to specific bacterial populations, with the possibility to create greater modulatory effects at large.
2020-09-28 | PXD015757 | Pride
Project description:According to RNA-seq results, application of vitamin D in the form of 25(OH)D in swine diet can be beneficial for myogenesis, energy production and muscle fibre formation by influencing TOR signalling pathway. However, the use of vitamin D in the form of 25(OH)D may reduce muscle respiratory capacity.
2023-01-01 | GSE201510 | GEO
Project description:The skeletal muscle growth and development is a very complicated but precisely regulated process with interwoven molecular mechanisms. Skeletal muscle is a very heterogeneous tissue that is made up of a large variety of functionally diverse fiber types. Muscle mass is therefore largely determined by the number and size of those fibres. These fibre characteristics are determined by hyperplasia before birth and by hypertrophy after. Around 65 dpc and three postnatal stages (newborn, 3 days; young, 60 days; and mature, 120 days) are key time points in swine skeletal muscle growth and development. We used microarrays to detail the global programme of gene expression underlying porcine skeletal muscle growth and development.
2011-07-01 | GSE24689 | GEO