Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Compensatory Evolution to DNA Replication Stress is Robust to Nutrient Availability

ABSTRACT: Compensatory Evolution to DNA Replication Stress is Robust to Nutrient Availability

PROVIDER: PRJEB87420 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ERR14827400_1.fastq.gz	Fastqsanger.gz
	ERR14827400_2.fastq.gz	Fastqsanger.gz
	ERR14827401_1.fastq.gz	Fastqsanger.gz
	ERR14827401_2.fastq.gz	Fastqsanger.gz
	ERR14827402_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 194

Similar Datasets

Compensatory Evolution to DNA Replication Stress is Robust to Nutrient Availability.

Project description:Evolutionary repair refers to the compensatory evolution that follows perturbations in cellular processes. While evolutionary trajectories are often reproducible, other studies suggest they are shaped by genotype-by-environment (GxE) interactions. Here, we test the predictability of evolutionary repair in response to DNA replication stress-a severe perturbation impairing the conserved mechanisms of DNA synthesis, resulting in genetic instability. We conducted high-throughput experimental evolution on Saccharomyces cerevisiae experiencing constitutive replication stress, grown under different glucose availabilities. We found that glucose levels impact the physiology and adaptation rate of replication stress mutants. However, the genetics of adaptation show remarkable robustness across environments. Recurrent mutations collectively recapitulated the fitness of evolved lines and are advantageous across macronutrient availability. We also identified a novel role of the mediator complex of RNA polymerase II in adaptation to replicative stress. Our results highlight the robustness and predictability of evolutionary repair mechanisms to DNA replication stress and provide new insights into the evolutionary aspects of genome stability, with potential implications for understanding cancer development.

| S-EPMC11565888 | biostudies-literature

Leishmania TORC1 links nutrient availability to differentiation into infective

Project description:Leishmania TORC1 links nutrient availability to differentiation into infective

2022-10-31 | MSV000090621 | MassIVE

Nutrient availability and grazing influence priority effects

Project description:Nutrient availability and grazing influence priority effects in aquatic microbial communities

| PRJEB58812 | ENA

Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability

Project description:Cancer cell metabolism is heavily influenced by microenvironmental factors, including nutrient availability. Therefore, knowledge of microenvironmental nutrient levels is essential to understand tumor metabolism. To measure the extracellular nutrient levels available to tumors, we developed a quantitative metabolomics method to measure the absolute concentrations of >118 metabolites in plasma and tumor interstitial fluid, the extracellular fluid that perfuses tumors. Comparison of nutrient levels in tumor interstitial fluid and plasma revealed that the nutrients available to tumors differ from those present in circulation. Further, by comparing interstitial fluid nutrient levels between autochthonous and transplant models of murine pancreatic and lung adenocarcinoma, we found that tumor type, anatomical location and animal diet affect local nutrient availability. These data provide a comprehensive characterization of the nutrients present in the tumor microenvironment of widely used models of lung and pancreatic cancer and identify factors that influence metabolite levels in tumors.

2019-01-03 | ST001119 | MetabolomicsWorkbench

Carbon source availability drives nutrient utilization in CD8+ T cells

Project description:Carbon source availability drives nutrient utilization in CD8+ T cells

| PRJNA843046 | ENA

Interdependent nutrient availability and steroid hormone signals facilitate root growth plasticity

Project description:Interdependent nutrient availability and steroid hormone signals facilitate root growth plasticity

| PRJNA470669 | ENA

Hfq CLASH uncovers sRNA-target interaction networks linked to nutrient availability adaptation

Project description:Hfq CLASH uncovers sRNA-target interaction networks linked to nutrient availability adaptation

| PRJNA507412 | ENA

Chaperone dependent coordination of nutrient sensing and energy metabolism by mTORC2

Project description:mTORC2 senses nutrients and coordinates substrate metabolism and macromolecule synthesis program with the availability of external nutrient availability. Knockdown of mTORC2 components and its chaperone partners impairs both nutrient sensing and downstrem metabolism/growth programs.

2020-01-23 | GSE93948 | GEO

Hfq CLASH uncovers sRNA-target interaction networks linked to nutrient availability adaptation [CLASH]

Project description:Hfq CLASH uncovers sRNA-target interaction networks linked to nutrient availability adaptation [CLASH]

| PRJNA507415 | ENA

Exercise prevents fatty liver by modifying the compensatory response of mitochondrial metabolism to excess substrate availability

Project description:Exercise prevents fatty liver by modifying the compensatory response of mitochondrial metabolism to excess substrate availability

| PRJNA702786 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data