Making Safety Decisions for a Sunscreen Active Ingredient Using Next-Generation Risk Assessment: Benzophenone-4 Case Study
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PROVIDER: PRJEB89670 | ENA |
REPOSITORIES: ENA
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Project description:High throughput transcriptomics using the TempO-Seq (TM) platform for dose response modelling of 3 different cell lines treated with the compound Benzophenone-4 as part of case study to explore the application of Next Generation Risk Assessment approaches for a sunscreen active ingredient. The data generated here was produced as one part of a toolbox of technologies to inform on bioactivity.
2025-07-31 | E-MTAB-15138 | biostudies-arrayexpress
Project description: Not available
| S-BSST2023 | biostudies-other
Project description:Ultraviolet (UV) light causes many eye diseases. Wearing sunglasses blocks <50% UV light from entering eyes. Skin sunscreens are banned for eye use due to irritation and safety concerns. Few sunscreens can be used in the eye to block UV light without compromising the eye functions. Herein, we modified poly(vinyl alcohol) (PVA), the active ingredient in commercial artificial tears, using naturally extracted aldehydes through Hantzsch’s reaction and obtained a PVA-syringaldehyde derivative that has a high sun protection factor (SPF 80), excellent UV resistance (>99%) and high transparency (84%) at 1 wt% in water, and a long half-life with little acute irritation and long-term safety when applied to female mouse eyes. Zebrafish protected by this polymer maintained healthy eye tissues and vision-guided behaviors after UV exposure. Polymer treatment on mice eyes effectively protected the retina from UV-induced damage, suggesting its potential as an eye sunscreen.
2026-04-29 | GSE329195 | GEO
Project description:A koji mold Aspergillus kawachii is used for making a Japanese distilled spirit, shochu. During making shochu, A. kawachii is grown in a solid-state culture comprised of steamed grains such as rice or barley, termed koji, to convert the starch to glucose and also to produce citric acid. During this process, cultivation temperature of A. kawachii is generally controlled by raising to 40M-BM-0C and then lowering to 30M-BM-0C. The cultivation at 40M-BM-0C and the following at lower temperature of 30M-BM-0C has important roles in the elevated activity of amylase and starting an accumulation of a large amount of citric acid, respectively. In this study, we investigated the effect of temperature on the gene expression of A. kawachii when barley was used as ingredient for making koji. The results of DNA microarray and gene ontology analysis showed that the expression of genes involved in the metabolic processes of glycerol, trehalose, and pentose phosphate that branch from glycolysis was down-regulated by shifting the cultivation temperature from 40M-BM-0C from 30M-BM-0C. In addition, reduction in the expression of the genes related with heat shock responses and increasing in the expression of the genes related with amino acid transport after the temperature lowering were found to be significant change. These results suggested that the cultivation at 40M-BM-0C is stressful event for the A. kawachii and the heat adaption lead to the depression of citric acid accumulation through activation of the branching pathways from glycolysis. The gene expression profile obtained in this study will help to understand the gene regulation during koji-making process to optimize A. kawachii as industrial microorganism. Gene expression of Aspergillus kawachii in barley koji was measured at 25, 26.5, and 44 hours at two different temperature control. Three independent experiments were performed at each time (25, 26.5, or 44 hours) using different barley koji for each expreriment.
2014-06-14 | E-GEOD-58454 | biostudies-arrayexpress
Project description:A koji mold Aspergillus kawachii is used for making a Japanese distilled spirit, shochu. During making shochu, A. kawachii is grown in a solid-state culture comprised of steamed grains such as rice or barley, termed koji, to convert the starch to glucose and also to produce citric acid. During this process, cultivation temperature of A. kawachii is generally controlled by raising to 40°C and then lowering to 30°C. The cultivation at 40°C and the following at lower temperature of 30°C has important roles in the elevated activity of amylase and starting an accumulation of a large amount of citric acid, respectively. In this study, we investigated the effect of temperature on the gene expression of A. kawachii when barley was used as ingredient for making koji. The results of DNA microarray and gene ontology analysis showed that the expression of genes involved in the metabolic processes of glycerol, trehalose, and pentose phosphate that branch from glycolysis was down-regulated by shifting the cultivation temperature from 40°C from 30°C. In addition, reduction in the expression of the genes related with heat shock responses and increasing in the expression of the genes related with amino acid transport after the temperature lowering were found to be significant change. These results suggested that the cultivation at 40°C is stressful event for the A. kawachii and the heat adaption lead to the depression of citric acid accumulation through activation of the branching pathways from glycolysis. The gene expression profile obtained in this study will help to understand the gene regulation during koji-making process to optimize A. kawachii as industrial microorganism.
2014-06-14 | GSE58454 | GEO
Project description: Not available
| S-EPMC8054615 | biostudies-literature
Project description:safety versus fear conditioning. Mice were trained with 4 unpaired (Safety) or paired (Fear) CS-US presentations over 3 days. Mice were killed by decapitation 4hrs after the last training session.
2008-11-28 | E-MEXP-1358 | biostudies-arrayexpress
Project description:This project aims to examine the impact of different interventions designed to help individualize colorectal cancer (CRC) screening decisions in adults aged 76-85. Clinicians will be assigned by chance to one of two arms. In the Intervention arm, clinician participants will complete a training course and will also be notified of patients in the target age group who are due for a discussion about CRC screening. In the Comparator arm, clinician participants will be notified of their patients in the target age group with an upcoming visit who are due for a discussion about CRC screening. The investigators expect that patients seen by clinicians in the intervention arm will report more involvement in the decision making process, be more knowledgeable about the risks and benefits of CRC screening, and will have better quality decisions. Further, the investigators expect that the physicians in the intervention arm will have greater confidence in and demonstrate more skills for conducting shared decision making conversations as compared to those in the control arm.
| 2306304 | ecrin-mdr-crc