Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Comparative genomics of Candida albicans Isolates From Colombia: Phylogenetic Insights and Resistance-Related Mutations

ABSTRACT: Comparative genomics of Candida albicans Isolates From Colombia

PROVIDER: PRJEB90182 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ERR15108238_1.fastq.gz	Fastqsanger.gz
	ERR15108238_2.fastq.gz	Fastqsanger.gz
	ERR15108239_1.fastq.gz	Fastqsanger.gz
	ERR15108239_2.fastq.gz	Fastqsanger.gz
	ERR15108240_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 26

Similar Datasets

Comparative genomics of clinical Candida albicans strains

Project description:Candida albicans is the most common fungal pathogen in humans. C.albicans tolerates aneuploidy of all of its chromosomes. Genome plasticity is a hallmark of C.albicans. It is an adaptation strategy of this species. But questions like the extent of such genomic variability, which genes contribute to the divergence, and what mechanisms drive the adaptive genetic change, are not well answered yet.

2010-11-05 | GSE18819 | GEO

Transcriptional profiling of two Candida albicans isolates in different growth condition

Project description:The study asked the question whether commensalism or pathogenicity of an opportunistic pathogen like Candida albicans, depend on strain specific traits or on the phenotypic and genomic plasticity of the genus as a whole. Transcriptional analysis performed upon different medium conditions (RPMI in presence or absence of FBS) indicated differentially expressed genes involved in adhesion, filamentous growth and biofilm formation. Both genome sequence and gene expression highlighted concordant changes in pathways related to invasiveness and filamentation. These results reflected marked differences in term of morphological features, environment adaptation and survival to phagocytosis. The results indicate that the genetic background of C. albicans may greatly affect its behaviour in terms of in vitro susceptibility to immune effector cells. Based on this approach, a more in depth understanding of fungal genetic makeup is achievable, thus allowing to establish the virulence potential of a given isolate and possibly to predict the outcome of C. albicans infection.

2018-02-14 | GSE85138 | GEO

Comparative genomics of a fluconazole-resistant Candida albicans strain CaLY350.

Project description:To investigate the diversity of gene contents of Candida albicans strain by array-based comparative genomic hybridization (array CGH; aCGH).

2014-06-24 | GSE48531 | GEO

Comparative genomics of ten clinical Candida albicans strains

2011-10-01 | GSE20509 | GEO

Transcription profiling of Candida albicans clinical isolates

Project description:Comparison of 20 clinical isolates of Candida albicans grown under identical growth conditions (biofilm growth conditions in RPMI 1640/10% serum)

2009-02-11 | E-MEXP-1933 | biostudies-arrayexpress

Comparative genomics of a fluconazole-resistant variant Candida albicans strain CaLY188.

Project description:To investigate the diversity of gene contents of Candida albicans strain by array-based comparative genomic hybridization (array CGH; aCGH).

2014-06-24 | GSE48529 | GEO

Comparative genomics of the srd1 null mutant Candida albicans strain CaLY202.

Project description:To investigate the diversity of gene contents of Candida albicans strain by array-based comparative genomic hybridization (array CGH; aCGH).

2014-06-24 | GSE48530 | GEO

Candida albicans

Project description:Candida albicans

| PRJNA308106 | ENA

Comparative genomics of a fluconazole-resistant Candida albicans strain CaLY350.

Project description:To investigate the diversity of gene contents of Candida albicans strain by array-based comparative genomic hybridization (array CGH; aCGH). A fluconazole-resistant Candida albicans strain CaLY350 was selected to carry out the comparative genomics microarray. Two-condition experiment, CaLY350 vs.SN152. Biological replicates: 2 control, 2 transfected, independently grown and harvested. One replicate per array.

2014-06-24 | E-GEOD-48531 | biostudies-arrayexpress

Genetic Insights into the Rheological Strength of Candida albicans Biofilms

Project description:The principal opportunistic human fungal pathogen Candida albicans forms biofilms resistant to antifungal therapeutics. Biofilms are a class of soft matter with viscoelastic properties and response to flow, but little is known regarding the genes contributing to these rheological phenotypes in fungal biofilms. Here, we identify C. albicans genes with deletion phenotypes of altered biofilm viscoelasticity. We analyzed mutants deleted for genes contributing to cell wall structure or extracellular matrix (ECM) production, and we identified increased elastic moduli, indicative of higher viscoelasticity, in strains singly deleted for PMR1, KRE5, and ALG11. PMR1 encodes a secretory pathway calcium pump. KRE5 encodes a UDP-glucose:glycoprotein glucosyltransferase, and ALG11 encodes alpha-1,2-mannosyltransferase. These mutants form less biofilm ECM by weight relative to wild type when cultured on agar. For these strains, biofilm morphology is smooth, with reduced hyphal formation. The mutants exhibit decreased resistance to the antifungal agent fluconazole relative to wild type biofilm cultures. To identify intracellular changes underlying these altered rheological properties, we globally profiled transcript levels in the respective mutants. Genes encoding membrane proteins were enriched in the set of transcripts differentially abundant in the alg11 deletion mutant. RNA levels are altered for genes associated with translation in the pmr1 deletion mutant and protein catabolism in the kre5 deletion strain. Genes involved in lipid metabolism and filamentous development are differentially expressed in cells from alg11, kre5, and pmr1 deletion mutant biofilms. Collectively, the data indicate C. albicans biofilm rheology as a phenotype affected by ECM production and cell morphology, while identifying genes for the investigation of mechanisms underlying properties of fungal biofilm viscoelasticity.

2024-10-21 | GSE276413 | GEO