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Modelling group 3 medulloblastoma post radiotherapy

ABSTRACT: Modelling group 3 medulloblastoma post radiotherapy

PROVIDER: PRJEB91360 | ENA |

REPOSITORIES: ENA

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Modelling group 3 medulloblastoma post radiotherapy

Project description:We have employed single cell RNA sequencing using the 10x Genomics platform to study the molecular mechanisms underlying resistance to treatment. In clinically relevant mouse models of G3 medulloblastoma, CT-guided fractionated radiotherapy was given to induce the clonal selection of radioresistant subpopulations. Comparison of recurrent and treatment naïve tumors revealed a prognostic gene expression signature reflective of radio-resistance.

2025-07-10 | E-MTAB-15292 | biostudies-arrayexpress

Effect of CALCOCO2 depletion in HDMB03 Group 3 medulloblastoma cells

Project description:Medulloblastoma (MB) is the most common malignant paediatric brain tumour, with Group 3 disease representing the most aggressive and therapy-refractory subtype. Despite intensive craniospinal radiotherapy, outcomes remain poor and the molecular basis of radioresistance is unclear. Here we identify CALCOCO2 as a key determinant of Group 3 MB aggressiveness and radiotherapy resistance. CALCOCO2 is markedly upregulated in Group 3 tumours, where high expression correlates with adverse clinical outcome. We show that CALCOCO2 is transcriptionally regulated by the developmental factor OTX2, defining a previously unrecognised axis that sustains a progenitor-like, transformation-permissive state. Functionally, nuclear CALCOCO2 promotes efficient repair of radiation-induced DNA double-strand breaks by engaging POLθ-dependent alternative end joining. Disruption of the CALCOCO2–POLθ pathway impairs DNA repair, sensitizes tumour cells to radiotherapy and suppresses tumour growth in vitro and in vivo. These findings uncover a developmentally wired DNA repair dependency in Group 3 MB and highlight POLθ inhibition as a rational strategy to overcome therapeutic resistance.

2026-09-01 | GSE324649 | GEO

Features of Group 3-like medulloblastoma mouse model [scRNA-Seq]

Project description:Group 3 medulloblastoma is the most aggressive among the four medulloblastoma subgroups, with poor prognosis and early metastasis making treatment particularly challenging. The lack of an immune-competent mouse model has hindered effective in vivo testing of potential drugs and mechanisms. Given the prevalent MYC overexpression in Group 3 medulloblastoma, we developed a Group 3-like medulloblastoma mouse model in C57BL/6J mice by overexpressing MYC in the cerebellum of newborn pups. This model provides a valuable tool for studying Group 3 medulloblastoma more effectively.

2026-03-25 | GSE292965 | GEO

Features of Group 3-like medulloblastoma mouse model [RNA-Seq]

2026-03-25 | GSE292964 | GEO

Group-specific cellular metabolism in Medulloblastoma

Project description:Group-specific cellular metabolism in Medulloblastoma

| PRJNA875953 | ENA

Prtg+ve Rhombic Lip Ventricular Zone Stem Cells Initiate and Maintain Group 3 Medulloblastoma

Project description:PRTG+ve cells show high self renewability in Group 3 medulloblastoma tumors. To access the proteins differentially expressed in this subset of cells, we sorted PRTG+ve and PRTG-ve cells by surface staining with Anti-PRTG antibody from Gr3 medulloblastoma xenografts.

2024-07-31 | PXD034890 | Pride

Effect of ZIC1 on group 3 medulloblastoma cell lines and granule neuron progenitor [ChIP-seq]

Project description:Investigate the DNA binding pattern as well as transcriptional consequences of ZIC1 and its medulloblastoma mutants in group 3 medulloblastoma cell lines and granule neuron progenitors

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Effect of ZIC1 on group 3 medulloblastoma cell lines and granule neuron progenitor [RNA-seq]

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Transcriptome analysis of Group 3 and 4 medulloblastoma orthotopic xenograft mice with digoxin treatment

Project description:RNA-seq data of Group 3 and 4 medulloblastoma with digoxin treatment.

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An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate [ChIP-seq]

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2020-06-11 | GSE132269 | GEO

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