Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Modelling group 3 medulloblastoma post radiotherapy

ABSTRACT: Modelling group 3 medulloblastoma post radiotherapy

PROVIDER: PRJEB91360 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Modelling group 3 medulloblastoma post radiotherapy

Project description:We have employed single cell RNA sequencing using the 10x Genomics platform to study the molecular mechanisms underlying resistance to treatment. In clinically relevant mouse models of G3 medulloblastoma, CT-guided fractionated radiotherapy was given to induce the clonal selection of radioresistant subpopulations. Comparison of recurrent and treatment naïve tumors revealed a prognostic gene expression signature reflective of radio-resistance.

2025-07-10 | E-MTAB-15292 | biostudies-arrayexpress

Features of Group 3-like medulloblastoma mouse model [scRNA-Seq]

Project description:Group 3 medulloblastoma is the most aggressive among the four medulloblastoma subgroups, with poor prognosis and early metastasis making treatment particularly challenging. The lack of an immune-competent mouse model has hindered effective in vivo testing of potential drugs and mechanisms. Given the prevalent MYC overexpression in Group 3 medulloblastoma, we developed a Group 3-like medulloblastoma mouse model in C57BL/6J mice by overexpressing MYC in the cerebellum of newborn pups. This model provides a valuable tool for studying Group 3 medulloblastoma more effectively.

2026-03-25 | GSE292965 | GEO

Features of Group 3-like medulloblastoma mouse model [RNA-Seq]

2026-03-25 | GSE292964 | GEO

Prtg+ve Rhombic Lip Ventricular Zone Stem Cells Initiate and Maintain Group 3 Medulloblastoma

Project description:PRTG+ve cells show high self renewability in Group 3 medulloblastoma tumors. To access the proteins differentially expressed in this subset of cells, we sorted PRTG+ve and PRTG-ve cells by surface staining with Anti-PRTG antibody from Gr3 medulloblastoma xenografts.

2024-07-31 | PXD034890 | Pride

Group-specific cellular metabolism in Medulloblastoma

Project description:Group-specific cellular metabolism in Medulloblastoma

| PRJNA875953 | ENA

Effect of ZIC1 on group 3 medulloblastoma cell lines and granule neuron progenitor [ChIP-seq]

Project description:Investigate the DNA binding pattern as well as transcriptional consequences of ZIC1 and its medulloblastoma mutants in group 3 medulloblastoma cell lines and granule neuron progenitors

2024-09-19 | GSE217638 | GEO

Effect of ZIC1 on group 3 medulloblastoma cell lines and granule neuron progenitor [RNA-seq]

2024-09-19 | GSE217571 | GEO

Transcriptome analysis of Group 3 and 4 medulloblastoma orthotopic xenograft mice with digoxin treatment

Project description:RNA-seq data of Group 3 and 4 medulloblastoma with digoxin treatment.

2018-10-30 | GSE115542 | GEO

An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate [ChIP-seq]

Project description:We evaluated changes in active and repressive histone modifications following the silencing of OTX2 in Group 3 medulloblastoma tumorspheres

2020-06-11 | GSE132269 | GEO

Unified rhombic lip origins of Group 3 and Group 4 medulloblastoma

Project description:Unified rhombic lip origins of Group 3 and Group 4 medulloblastoma

| PRJNA862940 | ENA