Project description:Our single-cell transcriptomic profiling study depicted the heterogeneity of human dermal blood vascular endothelial cells and molecularly refined individual blood vessel compartments.

2022-05-26 | E-MTAB-10137 | biostudies-arrayexpress

Single-cell transcriptomic analysis of CD8+ T cells from peripheral blood of WT and Dusp2-/- mice

Project description:Virtual memory CD8+ T (TVM) cells are a distinct subset of antigen-inexperienced cells with rapid effector potential, but their regulatory checkpoints remain elusive. Here, using single-cell transcriptomic profiling, we found that depletion of DUSP2 drives the expansion of CD44super-high TVM subset with heightened effector signatures.

2026-04-29 | GSE329034 | GEO

Dynamics of Virus-specific CD8+ T cells in the Human Nasal Cavity

Project description:The goal of this experiment is to compare the transcriptomic profile of CD8+ T cells isolated from the nasal cavity and whole blood at two different state, baseline and CD3/28 activated. This will allow us to characterise the unique features of CD8+ T cells in the nasal cavity. We isolated CD8+CD45RO+ T cells from fresh nasal turbinate samples and PBMCs of four healthy donors (1 Females, 45 years old; 3 Males, 24, 40 and 41 years old). Single-cell RNA sequencing was performed on both nasal and blood CD8+ CD45RO+ T cells, either directly or following overnight TCR-mediated stimulation with anti-CD3/CD28 beads.

2025-08-23 | E-MTAB-15436 | biostudies-arrayexpress

CITE-seq of human blood CD8+ T cells

Project description:The purpose of the experiment was to investigate the differentiation state gradient among antigen-experienced CD8+ T cells in healthy human blood. This was a sub-goal within a larger experiment, which aimed to investigate the clonal relationship between CD8+ T cells in blood and skin of matched donors. The blood T cells were sorted as CD8+ T cells (n=4) or CD3+ T cells (n=2), processed according to the 5´prime 10x genomic workflow, and sequenced at NGI Sweden.

2023-06-30 | E-MTAB-13034 | biostudies-arrayexpress

RNAseq of CD8+ and CD8- MAIT cells in human peripheral blood

Project description:RNAseq of CD8+ and CD8- MAIT cells in human peripheral blood

| PRJNA494706 | ENA

Human lung CD8+ T cells compared with paired non-naive peripheral blood CD8+ T cells

Project description:It is unknown whether human lung T cells recirculate or belong to a distinct tissue-specific population. This issue is important for understanding their role in protection against viral infection and their contribution to pathophysiology of lung diseases such as chronic obstructive pulmonary disease. By comparing transcriptional profiles of blood and lung CD8+ T cells, we aimed to reveal specific traits of lung CD8+ T cells. A total of 12 samples was analyzed: 10 patient samples (including 1 technical replicate) and 2 reference samples (including 1 technical replicate). Per patient (in total 3 patients), 3 paired samples were analyzed. These samples were non-naive peripheral blood CD8+ T cells (CD45R0+CD3+CD8+ T cells), memory-type lung CD8+ T cells (CD45R0+CD27+CD3+CD8+ T cells) and effector-type lung CD8+ T cells (CD45R0+CD27-CD3+CD8+ T cells). The reference population consisted of a mix of naive peripheral blood CD8+ T cells from 5 healthy donors.

2011-06-20 | E-GEOD-30027 | biostudies-arrayexpress

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