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ABSTRACT: RNASeq analysis of embryonic day 13.5 mouse thalamus, prethalamus and anterior cortex from control and Pax6-deleted embryos

PROVIDER: PRJEB9747 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR950085_1.fastq.gz	Fastqsanger.gz
	ERR950085_2.fastq.gz	Fastqsanger.gz
	ERR950086_1.fastq.gz	Fastqsanger.gz
	ERR950086_2.fastq.gz	Fastqsanger.gz
	ERR950087_1.fastq.gz	Fastqsanger.gz

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Project description:RNASeq analysis of embryonic day 13.5 mouse cerebral cortex from control and Pax6-deleted embryos

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Project description:Pax6 is a transcription factor with key functional roles in embryonic development. In order to identify downstream effectors of Pax6 in the developing cerebral cortex we performed microarray analysis. We compared gene expression profiles of cortical tissues isolated from wild type and Pax6-/- mouse embryos. In order to identify Pax6 downstream targets we carried out microarray analysis of Pax6-/- mutant mice. Pax6 is highly expressed in the mouse cerebral cortex at embryonic day E14.5, therefore we selected this tissue in order to compare gene expression profiles between wild type and Pax6-/- homozygous cortici. RNA samples were isolated from three mutant and three wild type embryos.

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Project description:Forelimbs were dissected from embryonic day (E) 13.5 Pax3-knockout and wild-type murine embryos (n=3 per genotype), homogenized, and proteins were fractionated into 5 samples (C, N, M, CS, and IN fractions). C, N, M, CS, and IN fractions for Pax3-KO (KO) and wild-type (WT) were analyzed by LC-MS/MS.

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