Pax6 mutant neocortex vs. wild type
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Robert Geffers
PROVIDER: E-GEOD-32271 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Cellular retinaldehyde-binding protein (CRALBP) is a direct downstream target of transcription factor Pax6.
Boppana Sridhar S Scheglov Alexander A Geffers Robert R Tarabykin Victor V
Biochimica et biophysica acta 20111004 2
<h4>Background</h4>Transcription factor Pax6 plays an essential role in the expression of other transcription factors, cell adhesion molecules and is crucial for neurogenesis in the developing forebrain. Analysis of gene expression profiles through microarray experiments in Pax6 mutants allowed us to focus on CRALBP, one of the many genes that were downregulated.<h4>Methods</h4>We studied the expression of CRALBP in wt and Pax6-/- mutants through in situ hybridization and immunohistochemistry. C ...[more]
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