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Long non-coding RNA Mir17hg positively regulates melanogenesis by inhibiting TGFβ receptor 2 under psychological stress

ABSTRACT: Long non-coding RNA Mir17hg positively regulates melanogenesis by inhibiting TGFβ receptor 2 under psychological stress

PROVIDER: PRJNA1010198 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR25778767_1.fastq.gz	Fastqsanger.gz
	SRR25778767_2.fastq.gz	Fastqsanger.gz
	SRR25778768_1.fastq.gz	Fastqsanger.gz
	SRR25778768_2.fastq.gz	Fastqsanger.gz
	SRR25778769_1.fastq.gz	Fastqsanger.gz

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Long non-coding RNA Mir17hg positively regulates melanogenesis by inhibiting TGFβ receptor 2 under psychological stress

Project description:Skin is the largest organ and it communicates with the brain through neural and humoral signals. Stress has been demonstrated to be the main cause of unhealthy hair cycles and depigmentation. In this study, We used a mouse model for chronic restraint stress (CRS) to observe its effect on pigmentation. After 12 weeks under stress, total RNA was extracted from the dorsal skin of three mice in each group. We uncovered 1,047 differentially expressed genes. Among these, 101 differentially expressed Long non-coding RNAs (lncRNAs) were identified. Further, we explored the effect of lncRNA Mir17hg on melanin production in vivo and in vitro, and proved that Mir17hg promotes melanogenesis by inhibiting TGFβR2.

2023-09-10 | GSE241826 | GEO

Psychological stress increases susceptibility to Staphylococcus aureus infection by the action of TGFβ to suppress immune acting fibroblasts [RNA-Seq]

Project description:Psychological stress results in increased susceptibility to infection yet the mechanisms responsible for this major healthcare burden are incompletely understood. In mice, stress induced by restraint increases infection by Staphylococcus aureus while adrenalectomy or chemical inhibition of adrenergic signaling blocks this response. Single-cell transcriptomics and lipidomic profiling of the skin after stress reveal fibroblasts undergoing adipogenesis are the major cell type responding to stress. Fibroblasts are critical to the increase in infection as adrenaline inhibits fibroblast Camp expression and bacterial killing, and stress did not increase infection in mice that lack Camp in fibroblasts. The suppression of the antimicrobial function of Camp in fibroblasts occurs due to activation of TGFβ signaling and is critical to the capacity of stress to increase susceptibility to infection since treatment of mice with a neutralizing TGFβ antibody or a TGFβ receptor inhibitor restores expression of Camp and alleviates increased susceptibility to infection. These data show that susceptibility to infection after psychological stress is due to a brain-skin axis that induces TGFβ and subsequently inhibits host defense by immune acting fibroblasts in the dermis. This identifies TGFβ as an unexpected target that can ameliorate increased bacterial infections associated with stress.

2025-05-29 | GSE270713 | GEO

Psychological stress increases susceptibility to Staphylococcus aureus infection by the action of TGFβ to suppress immune acting fibroblasts [scRNA-Seq]

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A MIR17HG-derived Long Noncoding RNA Provides an Essential Chromatin Scaffold for Protein Interaction and Myeloma Growth [array]

Project description:Long noncoding RNAs (lncRNA) can drive tumorigenesis and are susceptible to therapeutic intervention. Here, we used a large-scale CRISPR interference viability screen to interrogate cell growth dependency to lncRNA genes in multiple myeloma (MM), and identified a prominent role for the miR-17-92 cluster host gene (MIR17HG). We show that a MIR17HG-derived lncRNA, named lnc-17-92, is the main mediator of cell growth dependency acting in a microRNA- and DROSHA- independent manner. Lnc-17-92 provides a chromatin scaffold for the functional interaction between c-MYC and WDR82, thus promoting the expression of ACC1, the rate-limiting enzyme of de novo lipogenesis. Targeting MIR17HG pre-RNA with clinically applicable antisense molecules disrupts the transcriptional and functional activities of lnc-17-92, causing potent anti-tumor effects both in vitro and in vivo in three pre-clinical animal models, including a clinically relevant PDX-NSG mouse model. This study establishes a novel oncogenic function of MIR17HG and provides potent inhibitors for translation to clinical trials.

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A MIR17HG-derived Long Noncoding RNA Provides an Essential Chromatin Scaffold for Protein Interaction and Myeloma Growth [RNA-Seq]

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Human psychological stress plasma

Project description:Blood plasma was collected from 9 naval aviation students 24 hours prior to and no more than 20 minutes after Modular Egress Training (psychological stressor).

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IL-17 and TNF synergistically induce growth-associated cytokines in melanocytes while suppressing melanogenesis

Project description:In this study, we sought to determine how IL-17 and TNF influence normal human melanocytes, either alone, or with both cytokines together. We reveal a dichotomous effect of IL-17 and TNF, which not only elicit essential mitogenic cytokines but also suppress melanogenesis by down-regulating genes of melanogenesis pathway Comparison of one batch of primary human melanocyte line cultured in serum free media, treated with TNF and/or IL-17, for either 24 or 48 hours.

2013-06-15 | E-GEOD-40413 | biostudies-arrayexpress

IL-17 and TNF synergistically induce growth-associated cytokines in melanocytes while suppressing melanogenesis

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Heat promotes melanogenesis by increasing the paracrine effects in keratinocytes via the TRPV3/Ca2+/Hh signaling pathway

Project description:Global warming and rising temperature significantly increase the incidence of heat stress, which is known to affect the process of inflammation and aging. However, the effect of heat stress on skin melanogenesis is not fully known. We found that healthy foreskin tissues underwent significant pigmentation when exposed to 41℃. Furthermore, heat stress promoted melanogenesis in pigment cells by increasing the paracrine effects of keratinocytes. High-throughput RNA sequencing showed that heat stress activates the Hedgehog (Hh) signaling pathway in keratinocytes. The agonists of Hh signaling promote the paracrine effect of keratinocytes on melanogenesis. In addition, TRPV3 agonists activate the Hh signaling in keratinocytes and augment its paracrine effect on melanogenesis. The heat-induced activation of Hh signaling is dependent on TRPV3-mediated Ca2+ influx. Heat exposure promotes melanogenesis by increasing the paracrine effects in keratinocytes via the TRPV3/Ca2+/Hh signaling pathway. Our findings provide insights into the mechanisms of heat-induced skin pigmentation.

2023-05-20 | GSE229915 | GEO

Leukocyte gene expression variation as a function of psychological well-being II

Project description:Individual differences in basal leukocyte gene expression profiles as a function of hedonic and eudaimonic well-being, and psychological and social sub-dimensions of eudaimonic well-being. Gene expression profiling was carried out on peripheral blood mononuclear cell RNA samples collected from 122 healthy adults measured for hedonic and eudaimonic dimensions of well-being using the Short Flourishing Scale (Keyes, C (2014). The Mental Health Continuum-Short Form (MHC-SF) for adults). Higher values of the hedonic well-being scale indicate greater levels of positive affect, higher values of eudaimonic well-being scale indicate greater experience of purpose and meaning in life, higher values of social well-being scale indicate greater experience of social well-being in life, higher values of psychological well-being scale indicate greater experience of psychological well-being in life, greater TotalMHCSF scores indicate greater experience of all forms of well-being measured by the MHC-SF, the FlourishGroup indicates idividuals showing flourishing mental health as defined by the MHC-SF scoring instructions referenced above, greater BrownPsychological scores indicate greater experience of psychological well-being as measured by the MHC-SF with an alternative scoring, and greater BrownSocial scores indicate greater experience of social well-being as measured by the MHC-SF with an alternative scoring.

2015-03-28 | E-GEOD-55762 | biostudies-arrayexpress

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