Rattus norvegicus
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ABSTRACT:
PROVIDER: PRJNA101085 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Microarray profiling single and repeated immobilization stress responses in gene expression in rat adrenal medulla Keywords: Stress responses
2008-07-15 | GSE8184 | GEO
Project description:Microarray profiling single and repeated immobilization stress responses in gene expression in rat adrenal medulla Experiment Overall Design: Immobilization stress (IMO) was performed with 2-hour once and 2-hour daily for 6 days repeated. Control groups were not exposed to stress (absolute controls). Following the last IMO, rats were euthanized by decapitation and both adrenal medulla tissues were dissected from the animal. Total RNA were isolated and the array experiments were done by Affymetrix. Data analysis will be performed by GeneTraffic program.
2008-10-18 | E-GEOD-8184 | biostudies-arrayexpress
Project description:Spinal gene expression signature in male wistar rats exposed to repeated psychological stress
| PRJNA281012 | ENA
Project description:Stress is a major risk factor for many cardiovascular and neuropsyhological disorders, and involved changes in gene expression Determine target genes affected by single or repeated immboilization stress. Stress triggers alterations in gene expresssion of many proteins, especially transcription factors. The target genes of repeated stress partially overlap, but differ from those altered by single stress. Sprague Dawley male rats were exposed to single 2 hr immobilization stress or 2 hrs immbolization stress each for six consecultive days. Controls for single stress were untreated, and controls for repeated stress were handled for six days. Keywords: dose response
2006-01-13 | GSE4038 | GEO
Project description:Stress is a major risk factor for many cardiovascular and neuropsyhological disorders, and involved changes in gene expression; Determine target genes affected by single or repeated immboilization stress. Stress triggers alterations in gene expresssion of many proteins, especially transcription factors. The target genes of repeated stress partially overlap, but differ from those altered by single stress. Sprague Dawley male rats were exposed to single 2 hr immobilization stress or 2 hrs immbolization stress each for six consecultive days. Controls for single stress were untreated, and controls for repeated stress were handled for six days.
2008-06-12 | E-GEOD-4038 | biostudies-arrayexpress
Project description:Spinal microRNA expression signature in male wistar rats exposed to repeated psychological stress
| PRJNA281011 | ENA
Project description:Zonal Gene Expression and Gene Regulatory Network Responses in Centrilobular and Periportal Hepatocytes Following Repeated Exposure to TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin)
| PRJNA294182 | ENA
Project description:Inflammation is a key component of pathological angiogenesis. Here we induce cornea neovascularisation using sutures placed into the cornea, and sutures are removed to induce a regression phase. We used whole transcriptome microarray to monitor gene expression profies of several genes
2016-08-18 | GSE81418 | GEO
Project description:Knee osteoarthritis (KOA), as a degenerative multifactorial disease, affects the quality of life and mental health of patients, and also brings a huge socioeconomic burden. Treating synovitis have shown promise as anti-inflammatory therapeutics in mitigating OA symptoms and disease progression. Here, by analysing synovial single-cell sequencing (scRNA-seq) data from KOA, we found that synovial fibroblasts (FLS) in OA synovium showed a distinct pro-inflammatory phenotype. We collected synovial tissue from patients with clinical OA as well as from healthy donors, and histological examination was consistent with findings in scRNA-seq. Inspired by recent cross-tissue fibroblast lineage studies, we identified by sequencing that healthy FLS in synovial tissues share transcriptome-level similarities with dermal fibroblasts (DFb). Subsequently, we revealed the local as well as systemic distribution of intra-articular injected DFbs by constructing/extracting two types of rat fibroblasts (luciferase DFbs as well as GFP DFbs). The results demonstrate that DFbs can be locally retained in the synovium for up to three weeks following targeted engrafting on it. And intra-articular injection does not result in DFbs migration to vital organs or the occurrence of histological changes in these organs. A rat model of KOA was constructed by anterior cruciate ligament transection (ACLT) in order to study the therapeutic effect of DFbs on KOA. After injection, the rats showed improvement in painful gait. In addition, histological as well as imaging results showed reduced synovitis and improvement in articular cartilage. Finally we verified the protective effect of DFbs on cytokine-stimulated chondrocytes in a co-culture system.
2026-06-24 | GSE304724 | GEO