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CD301b+ monocyte-derived dendritic cells mediate resistance to radiotherapy

ABSTRACT: CD301b+ monocyte-derived dendritic cells mediate resistance to radiotherapy

PROVIDER: PRJNA1017500 | ENA |

REPOSITORIES: ENA

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CD301b+ monocyte-derived dendritic cells mediate resistance to radiotherapy

Project description:CD301b+ monocyte-derived dendritic cells mediate resistance to radiotherapy The objective of this experiment was to evaluate the transcriptional changes in DC2s and TAMs cells following radiation in B16F1 tumors

2025-03-11 | GSE243263 | GEO

CD301b+ monocyte-derived dendritic cells mediate resistance to radiotherapy

Project description:CD301b+ monocyte-derived dendritic cells mediate resistance to radiotherapy

| PRJNA1018816 | ENA

CD301b+ monocyte-derived dendritic cells mediate resistance to radiotherapy

Project description:Monocytes infiltrating tumors acquire various states that distinctly impact cancer treatment. Here, we show that resistance of tumors to radiotherapy (RT) is controlled by the accumulation of monocyte-derived dendritic cells (moDCs). These moDCs are characterized by the expression of CD301b and have a superior capacity to generate regulatory T cells (Tregs). Accordingly, moDC depletion limits Treg generation and improves the therapeutic outcome of RT. Mechanistically, we demonstrate that granulocyte-macrophage colony-stimulating factor (GM-CSF) derived from radioresistant tumor cells following RT is necessary for the accumulation of moDCs. Our results unravel the immunosuppressive function of moDCs and identify GM-CSF as an immunotherapeutic target during RT.

2025-03-11 | GSE243502 | GEO

Rapid Monocyte Recruitment Dictates the Therapeutic Efficacy of Focal Radiotherapy

Project description:The recruitment of monocytes and their differentiation into immunosuppressive cells is associated with the negative outcome of non-conformal radiotherapy (RT). However, non-conformal RT is irrelevant in the clinic, and little is known about the role of monocytes following radiotherapy modes used in patients, such as conformal radiotherapy (CRT). Here, we investigated the acute immune infiltration post-CRT. Contrary to non-conformal RT approaches, we found that CRT induces a rapid and robust recruitment of monocytes to the tumor that minimally differentiate into tumor-associated macrophages (TAM) or dendritic cells (DC), but instead upregulate major histocompatibility complex II (MHCII) and costimulatory molecules. We establish that these large numbers of infiltrating monocytes are responsible for increasing type I interferon in the tumor microenvironment (TME), activation of CD8+ T cells and the reduction in tumor burden. Importantly, we demonstrate that rapid monocyte infiltration to the TME is hindered when RT inadvertently affects healthy tissues. Our results unravel a positive role of monocytes during clinically relevant modes of RT and demonstrate that limiting exposure of healthy tissues to radiation has a positive therapeutic effect on the overall immune response within the tumor.

2022-06-30 | MSV000089775 | MassIVE

Monocyte Derived Dendritic Cell Maturation

Project description:Human monocyte derived dendritic cells matured via galectin-1 or LPS. Keywords: dendritic cell maturation

2006-08-02 | GSE4984 | GEO

Lung macrophages mediate helminth resistance through differential activation of recruited monocyte-derived alveolar macrophages and arginine depletion

Project description:Lung macrophages mediate helminth resistance through differential activation of recruited monocyte-derived alveolar macrophages and arginine depletion

2022-01-13 | GSE189674 | GEO

Quantitative analysis of large-scale proteomic changes in LPS-activated monocyte-derived dendritic cells: A SWATH-MS study

Project description:Determination of global alterations in monocyte-derived dendritic cells in response to stimulation with lipopolysaccharide using SWATH-MS to provide insight into cellular mechanism driving dendritic cell maturation

2019-03-18 | PXD008898 | Pride

Transcriptome profiles of mouse and human monocyte and dendritic cell subsets

Project description:This SuperSeries is composed of the following subset Series: GSE35457: Transcriptome profiles of mouse and human monocyte and dendritic cell subsets (human data) GSE35458: Transcriptome profiles of mouse and human monocyte and dendritic cell subsets (mouse data) Refer to individual Series

2012-07-11 | E-GEOD-35459 | biostudies-arrayexpress

Comparison of human plasmacytoid dendritic cells and monocyte-derived dendritic cells

Project description:Comparison of human plasmacytoid dendritic cells and monocyte-derived dendritic cells

| PRJEB66498 | ENA

miRCURY LNATM microRNA Array (7th Gen) profiling of monocyte-derived macrophages and monocyte-derived dendritic cells.

Project description:To examine the miRNA changes that occur during macrophage and dendritic cell differentiation we used the miRCURY LNATM microRNA Array (7th Gen) to profile monocyte-derived macrophages and monocyte-derived dendritic cells. Of the 2046 probes present on the assay, we detected expression of ~400 (20%) miRNAs across all samples.

2014-12-01 | GSE60839 | GEO

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