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Transposable elements silencing by the histone demethylase dLSD1 is required to achieve normal wing size

ABSTRACT: Transposable elements silencing by the histone demethylase dLSD1 is required to achieve normal wing size

PROVIDER: PRJNA1023181 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26254985_1.fastq.gz	Fastqsanger.gz
	SRR26254985_2.fastq.gz	Fastqsanger.gz
	SRR26254986_1.fastq.gz	Fastqsanger.gz
	SRR26254986_2.fastq.gz	Fastqsanger.gz
	SRR26254987_1.fastq.gz	Fastqsanger.gz

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Similar Datasets

Transposable elements silencing by the histone demethylase dLSD1 is required to achieve normal wing size

Project description:Determination of tissue size depends on the proper response of cells to a wide array of external and internal signals. Chromatin acts as a platform/substrate of signal integration and storage. Signal transduction pathways converge upon chromatin modifying enzymes and transcription factors to reprogram gene expression. However, little is known about the role of chromatin modifying factors in determining tissue size. Here, we show that loss of function of the histone demethylase dLSD1 results in a significant reduction of Drosophila wing size due to a decreased cell number. We show that dLSD1 depletion affects proliferation and induces DNA damage in larval wing imaginal discs. Through transcriptomics analysis, we find that dLSD1 controls the expression of multiple gene networks in wing imaginal discs. We then show that normal dLsd1 function contributes to repressing Transposable Element (TE) transcription and mobility. Additionally, our results suggest that increased TE mobility due to dLsd1 depletion contributes directly to altered organ size.

2025-02-11 | GSE244445 | GEO

The histone demethylase dLsd1 regulates organ size by silencing transposable elements.

Project description:The specific role of chromatin modifying factors in the timely execution of transcriptional changes in gene expression to regulate organ size remains largely unknown. Here, we report that in Drosophila melanogaster depletion of the histone demethylase dLsd1 results in the reduction of wing size. dLsd1 depletion affects cell proliferation and causes an increase in DNA damage and cell death. Mechanistically, we have identified Transposable Elements (TEs) as critical dLsd1 targets for organ size determination. We found that upon dLsd1 loss many TE families are upregulated, and new TE insertions appear. By blocking this new TE activity, we could rescue the wing size phenotype. Collectively, our results reveal that the histone demethylase dLsd1 and maintenance of TE homeostasis are required to ensure proper wing size.

| S-EPMC11842725 | biostudies-literature

The histone demethylase dLSD1 is required to achieve normal wing size and to silence Transposable Elements in epithelial cells

Project description:LSD1 regulates transposable elements

| PRJEB67336 | ENA

Genome-wide study of the role of the histone demethylase dLsd1 in oogenesis

Project description:To study the effect of dLsd1 knockdown on gene expression in oogenesis, we performed transcripts profiling by microarray in wild type ovaries and ovaries depleted for dLsd1.

2019-11-21 | GSE110751 | GEO

Genome-wide study of the role of the histone demethylase dLsd1 in oogenesis

Project description:The histone demethylase LSD1 is a key chromatin regulator that plays a crucial role in development. It has been shown to act both as a co-repressor and a co-activator of genes expression and to affect the expression of many genes important for development. In Drosophila, dLsd1 is essential for oogenesis; however, our current knowledge of dLsd1 function is insufficient to explain its precise role in the ovary. To better define the role of dLsd1 in oogenesis, we performed genome-wide analysis of dLsd1 binding in the ovary by Chromatin Immunoprecipitation followed by sequencing (ChIP-Seq).

2019-02-08 | GSE110331 | GEO

RNA-seq of Drosophila melanogaster testes upon knock-down of dCoREST, dLSD1 and controls

Project description:Expression of dCoREST or dLSD1 was reduced by RNAi in Drosophila testes and changes to gene transcription were determined by RNA-seq.

2019-01-01 | E-MTAB-7439 | biostudies-arrayexpress

Genome-wide study of the role of the histone demethylase dLsd1 in oogenesis

Project description:Genome-wide study of the role of the histone demethylase dLsd1 in oogenesis

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Genome-wide study of the role of the histone demethylase dLsd1 in oogenesis

Project description:Genome-wide study of the role of the histone demethylase dLsd1 in oogenesis

| PRJNA433482 | ENA

SILKWORM WING SCALES LC-MSMS ANALYSIS RAW DATA

Project description:To identify the cuticular proteins in developing wing scales of Bombyx mori, we performed LC-MS/MS analysis of dissoliving developing wing scales from Bombyx mori

2021-04-26 | PXD024362 | Pride

ChIP-seq of GFP-tagged dCoREST, dLSD1, dL(3)mbt and dG9a in D. melanogaster S2 cell lines

Project description:We employed CRISPR/Cas-mediated genome editing to generate S2 cell lines expressing GFP-tagged dCoREST, dL(3)mbt, dLSD1 and dG9a, respectively. This allowed us to determine the genome-wide binding profiles for these proteins by ChIP-seq using the same antibody (anti-GFP) in each case.

2019-11-04 | E-MTAB-8341 | biostudies-arrayexpress

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