Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Promiscuous Oxidosqualene Cyclase Involved in Cyclization of Dioxidosqualene to Heterocyclic Triterpenes in Neoalsomitra integrifoliola

PROVIDER: PRJNA1024411 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR26286701_1.fastq.gz	Fastqsanger.gz
	SRR26286701_2.fastq.gz	Fastqsanger.gz
	SRR26286702_1.fastq.gz	Fastqsanger.gz
	SRR26286702_2.fastq.gz	Fastqsanger.gz
	SRR26286703_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 30

Similar Datasets

Oxidosqualene cyclase targeting compound in Leishmania

Project description:Overexpression library screen - Oxidosqualene cyclase targeting compound in Leishmania donovani

| PRJEB37256 | ENA

Oxidosqualene cyclase targeting compound in Leishmania

Project description:Whole genome sequencing of resistant lines - Oxidosqualene cyclase targeting compound in Leishmania donovani

| PRJEB37435 | ENA

Project description:Identification and Cloning of a Putative Male Fertility Gene Encoding an Oxidosqualene Cyclase in Qingke

| PRJNA979839 | ENA

Harnessing Apple Cell Suspension Cultures in Bioreactors for Triterpene Production: Transcriptomic Insights into Biomass and Triterpene Biosynthesis

Project description:Plant cell suspension cultures offer a sustainable method for producing valuable secondary metabolites, such as bioactive pentacyclic triterpenes. This study established a high-triterpene-yielding cell suspension culture from the apple cultivar "Cox Orange Pippin." Through transcriptomic analysis and triterpene profiling across growth phases, we uncovered complex regulatory networks that govern biomass production and triterpene biosynthesis. Key biological processes, including cell cycle regulation, cell wall biosynthesis, lipid metabolism, and stress response mechanisms, play pivotal roles in culture dynamics. Differential gene expression linked to these processes revealed how the culture adapts to growth conditions and nutrient availability at each growth phase. Methyl jasmonate elicitation enhanced phenylpropanoid and flavonoid biosynthesis, along with specific triterpene production pathways, highlighting its potential for optimizing secondary metabolite production. Key enzymes, including oxidosqualene cyclase 4 and a putative C-2α hydroxylase, emerged as promising targets for future metabolic engineering of triterpene pathways. This study represents the first in-depth report on the molecular mechanisms underlying plant cell growth in bioreactors, specially focusing on a non-model plant species . These findings reveal key regulatory pathways in biomass accumulation and triterpene production, offering insights to optimize bioreactor cultures for industrial use. The research opens new avenues to enhance triterpene yields via targeted metabolic engineering and innovative bioprocessing strategies, paving the way for efficient large-scale production.

2025-04-17 | GSE281877 | GEO

Trypanosoma brucei transcriptome changes upon exposure to the aminomethyl-benzoxaborole AN3057

Project description:Benzoxaboroles (BoBs) feature a boron-heterocyclic core and are an important recent innovation in the development of drugs against a range of pathogens and other pathologies. A broad spectrum of pharmacology is associated with chemically diverse BoB derivatives and includes multiple modes-of-action and targets. However, a consensus MoA for BoBs targeting evolutionarily diverse protozoan pathogens has emerged with the identification of CPSF3/CPSF73 in the CPSF complex in both apicomplexan and kinetoplastida parasites. We have detected a functional connection between protein sumoylation and the BoB boron-heterocyclic scaffold using comprehensive genetic screens in Trypanosoma brucei. Strikingly, as part of this sumoylation response, members of the CPSF complex are specifically and rapidly destabilised in a SUMO and proteosome-dependent manner. Here we deposit RNAseq data quantifying the effects of the aminomethyl-benzoxaborole AN3057 exposure on the transcriptome landscape in T. brucei. Specifically, T. brucei bloodstream-form cells in logarithmic growth phase were treated with 400 nm AN3057 (3 × EC50 determined after 24h) for 20 min (T20) and 60 min (T60), respectively. Nontreated control cells were prepared in parallel. All samples were in 2 biological replicates.

2024-03-08 | E-MTAB-13843 | biostudies-arrayexpress

Project description:selected nitrogen-heterocyclic in coal gasification wastewater

| PRJNA511719 | ENA

Project description:high throughput sequencing for nitrogen heterocyclic compounds- indole

| PRJNA482768 | ENA

lake water metagenome

Project description:MIB cyclase gene amplicon sequencing

| PRJDB8900 | ENA

Homo sapiens

Project description:Promiscuous RNA binding by PRC2

| PRJNA217298 | ENA

Expression data from PU.1low URE-/- AML cell line after treatment with small molecule acting as PU.1 inhibitor

Project description:Downregulation of the hematopoietic transcription factor PU.1 in PU.1 low acute myeloid leukemia cells (AML) by novel heterocyclic diamidines or PU.1 inhibitors leads to decrease cell proliferation and apoptosis, representing a new therapeutic strategy for AML treatment. These inhibitors induces decreased PU.1 binding on its target sites, as well as deregulation in PU.1 canonical target genes We used microarray to identify the pathways deregulated after drug treatment.

2017-12-07 | GSE77651 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data