Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptome of nonpregnant myometrial specimens with or without the medroxyprogesterone treament

ABSTRACT: Transcriptome of nonpregnant myometrial specimens with or without the medroxyprogesterone treament

PROVIDER: PRJNA1024464 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR26296252_1.fastq.gz	Fastqsanger.gz
	SRR26296252_2.fastq.gz	Fastqsanger.gz
	SRR26296253_1.fastq.gz	Fastqsanger.gz
	SRR26296253_2.fastq.gz	Fastqsanger.gz
	SRR26296254_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 86

Similar Datasets

Transcriptome of nonpregnant myometrial specimens with or without the medroxyprogesterone treament

Project description:Timely control of parturition is crucial for maternal and fetal health. Failures on this biological process often result in pregnancy complications including preterm birth, labor dystocia, and health disorders on newborn babies. The myometrium is the muscular structure of the uterus maintaining uterine structural integrity and providing contractile force for parturition. The myometrial structure changes in adaptation to the pregnancy via stage-specific transcriptomic profiles. Progesterone signaling plays a crucial role in myometrial remodeling. The present study profiles the transcriptome of human myometrial specimens that are expected to manifest a wide spectrum of progesterone signaling via the RNAseq assay.

2024-10-10 | GSE244728 | GEO

Myometrial specimens

Project description:Myometrial specimens

| PRJNA1024460 | ENA

The PGR occupancy profiles in nonpregnant and gravid human myometrial tissues

Project description:Profiles of PGR genome occupancy in human myometrial specimens were documented by ChIP-seq to investigate downstream targets of the progesterone receptor and candidate partner transcription regulators at the nonpregnant and term pregnant stages.

2019-11-28 | GSE137550 | GEO

Transcriptomic profiles of nonpregnant and term pregnant human myometrial tissues

Project description:The myometrium undergoes structural and functional remodeling during pregnancy. We hypothesize that myometrial genomic elements alter correspondingly in preparation for parturition. Human myometrial tissues from nonpregnant (NP) and term pregnant (TP) human subjects were subject to RNAseq, ATAC-seq and PGR ChIP-seq assays to profile transcriptome, assessible genome and PGR occupancy.

2019-11-28 | GSE137551 | GEO

Nonpregnant and term pregnant human myometrial tissues

Project description:Nonpregnant and term pregnant human myometrial tissues

| PRJNA565907 | ENA

Transcriptomic profile of the term pregnant human myometrial specimens

Project description:Transcriptomic profile of the term pregnant human myometrial specimens

| PRJNA1024462 | ENA

Profiling open chromatin regions in human myometrial tissues

Project description:The open chromatin regions of nonpregnant and term pregnant human myometrial tissues were assessed by ATAC-seq to gain insight on potential genome regulatory elements in vivo. patterns of accessible genome change between NP and TP myometrium, leading to altered enrichment of binding motifs for hormone and muscle regulators such as the progesterone receptor (PGR), Krüppel-like factors and MEF2A transcription factors.

2019-11-28 | GSE137549 | GEO

Transcriptomic profile of the term pregnant human myometrial specimens

Project description:Timely control of parturition is crucial for maternal and fetal health. Failures on this biological process often result in pregnancy complications including preterm birth, labor dystocia, and health disorders on newborn babies. The myometrium is the muscular structure of the uterus maintaining uterine structural integrity and providing contractile force for parturition. The myometrial structure changes in adaptation to the pregnancy via stage-specific transcriptomic profiles. Data from the mouse model indicate that changes of myometrial epigenomic landscape precedes the adoption of stage-specific gene expression pattern at term. The present study documents the transcriptomic profile and epigenomic landscape of term pregnant myometrial tissues and functionally characterize a subset of putative enhancers to further understand the enhancer-gene interaction in human the myometrium.

2024-10-10 | GSE244726 | GEO

Genome-wide chromatin conformation capture of the term pregnant human myometrial specimens

Project description:Timely control of parturition is crucial for maternal and fetal health. Failures on this biological process often result in pregnancy complications including preterm birth, labor dystocia, and health disorders on newborn babies. The myometrium is the muscular structure of the uterus maintaining uterine structural integrity and providing contractile force for parturition. The myometrial structure changes in adaptation to the pregnancy via stage-specific transcriptomic profiles. Data from the mouse model indicate that changes of myometrial epigenomic landscape precedes the adoption of stage-specific gene expression pattern at term. The present study documents the chromatin interaction profiles in the term pregnant not in labor human myometrial tissues at a genome-wide scale.

2024-10-10 | GSE244731 | GEO

Genome-wide chromatin conformation capture of the term pregnant human myometrial specimens

Project description:Genome-wide chromatin conformation capture of the term pregnant human myometrial specimens

| PRJNA1024466 | ENA