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Transcriptional profiling of striatum from a zQ175 KI mouse model of Huntington's disease with or without homozygous knockout of the Msh3 gene

ABSTRACT: Transcriptional profiling of striatum from a zQ175 KI mouse model of Huntington's disease with or without homozygous knockout of the Msh3 gene

PROVIDER: PRJNA1028632 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26401116_1.fastq.gz	Fastqsanger.gz
	SRR26401116_2.fastq.gz	Fastqsanger.gz
	SRR26401117_1.fastq.gz	Fastqsanger.gz
	SRR26401117_2.fastq.gz	Fastqsanger.gz
	SRR26401118_1.fastq.gz	Fastqsanger.gz

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Transcriptional profiling of striatum from a zQ175 KI mouse model of Huntington's disease with or without homozygous knockout of the Msh3 gene

Project description:Previous studies have suggested a strong association between lower MSH3 expression, reduced somatic repeat expansion, and slower disease onset and progression. The effects of a homozygous knock-out in the Msh3 gene on transcriptome phenotypes in striatum in six-month-old WT and zQ175 mice were studied. Striatum was isolated from 6-month-old mice. Transcriptomic analysis (RNASeq) was performed on four genotypes with 8 replicates per genotype: WT (WT for Htt and Msh3), zQ175 (zQ175 for Htt, WT for Msh3), WT.Msh3.HOM (WT for Htt, Homozygous for Msh3 KO), and zQ175.Msh3.HOM (zQ175 for Htt, Homozygous for Msh3 KO).

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