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Exploring Epigenetic Changes in the Development of Gemcitabine Resistance [AsPC1R_vs_AsPC1_CUTTAG]

ABSTRACT: Exploring Epigenetic Changes in the Development of Gemcitabine Resistance [AsPC1R_vs_AsPC1_CUTTAG]

PROVIDER: PRJNA1036552 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26700132_1.fastq.gz	Fastqsanger.gz
	SRR26700132_2.fastq.gz	Fastqsanger.gz
	SRR26700133_1.fastq.gz	Fastqsanger.gz
	SRR26700133_2.fastq.gz	Fastqsanger.gz
	SRR26700134_1.fastq.gz	Fastqsanger.gz

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Project description:To elucidate the epigenetic events, particularly the dynamic alterations in chromatin states during the development of gemcitabine resistance in pancreatic cancer cells, both the parental SW1990 cells and the gemcitabine-resistant counterparts, SW1990R cells, were employed for mapping of the histone modification landscape. The CUT&Tag-seq technology was used for precise detection of histone marks, including H3K4me1 (associated with enhancers), H3K27ac (related to active enhancers and promoters), H3K4me3 (linked to PolII-bound and CpG-rich promoters), H3K9me3 (associated with heterochromatin regions), and H3K27me3 (indicative of Polycomb inhibition).

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