Project description:Members of the genus Acinetobacter drag attention due to their importance in microbial pathology and biotechnology. OmpA is a porin with multifaceted functions in different species of Acinetobacter. In this study we identified this protein in Acinetobacter sp. SA01, an efficient phenol degrader strain, in different cellular and sub-cellular compartments (such as OM, OMV, biofilm and extracellular environment). Differential expression of proteins, including OmpA, under two conditions of phenol and ethanol supplementation was assessed using shotgun proteomics.
Project description:After treating human ovarian cancer cells A2780 and ES2 with YY-15, high-throughput sequencing technology was employed. The transcriptome analysis revealed that YY-15 does not exert its anti-tumor effect solely through telomere dysfunction, but instead simultaneously regulates cell cycle, senescence, apoptosis, and metabolic-related signaling pathways, thereby synergistically inducing the death of ovarian cancer cells.
