Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Cell cycle checkpoint proficiency of endometrial cancer cells [bulk RNA-Seq]

ABSTRACT: Cell cycle checkpoint proficiency of endometrial cancer cells [bulk RNA-Seq]

PROVIDER: PRJNA1040329 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR26830900_1.fastq.gz	Fastqsanger.gz
	SRR26830900_2.fastq.gz	Fastqsanger.gz
	SRR26830901_1.fastq.gz	Fastqsanger.gz
	SRR26830901_2.fastq.gz	Fastqsanger.gz
	SRR26830904_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 72

Similar Datasets

Cell cycle checkpoint proficiency of endometrial cancer cells

Project description:Cell cycle checkpoint proficiency of endometrial cancer cells

| PRJNA1040325 | ENA

Cell cycle checkpoint proficiency of endometrial cancer cells [WES]

Project description:Cell cycle checkpoint proficiency of endometrial cancer cells [WES]

| PRJNA1040328 | ENA

Cell cycle checkpoint proficiency of endometrial cancer cells [bulk RNA-Seq]

Project description:Endometrial cancers (EC) are the most common gynecologic malignancy in the US. Most ECs harbor limited targetable somatic alterations, and are often grouped by histology (endometrioid, serous, or clear cell), mismatch repair, or TP53 status, none of which perfectly predict therapeutic response. A better mechanistic understanding of the key functional defects in ECs and more therapies with which to engage those targets in advanced stage EC are needed. Here we utilize functional, transcriptomic and genomic assays on a panel of EC cell lines and patient-derived organoids across EC histologic and genomic subtypes to characterize the TP53 and RB1 cell cycle regulatory proficiency and therapeutic vulnerabilities in this disease. We were surprised to find that TP53 genomic and functional status has little predictive capacity for EC therapeutic response. Rather, RB regulatory status correlated better with response to G1/S targeted therapies.

2025-01-21 | GSE247791 | GEO

Cell cycle checkpoint proficiency of endometrial cancer cells [WES]

2025-01-21 | GSE247792 | GEO

Cell cycle checkpoint proficiency of endometrial cancer cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2025-01-21 | GSE247793 | GEO

Mre11 suppresses replication stress and gene amplification proficiency

Project description:Gene amplification, copy-number increases of particular genes and surrounding genomic segments, promotes cancer progression and acquired therapy resistance. Thus, understanding genetic traits that confer gene amplification proficiency is important. The primary step for gene amplification is spontaneous DNA rearrangements initiated by DNA breaks. Here we show that mammalian cells became gene amplification-proficient when we knocked down Mre11/Rad50/Nbs1 (MRN) complex, a multifunctional complex that guards the genome from DNA breaks. Cells with reduced Mre11 experienced severe replication stress, with marked increases of single-stranded breaks followed by double-stranded breaks during DNA replication. Such breaks underlay for the increase in spontaneous gene amplification. Other traits associated with replication stress, such as impaired intra-S phase checkpoint and global transcriptional changes in DNA metabolism genes also contributed to gene amplification proficiency. Our results define Mre11 deficiency as a cause of replication stress and gene amplification proficiency and provide a candidate marker for aggressive cancer phenotypes. We sequenced four samples: 2 control, GFP-expressing samples and 2 Mre11 knockdown cells

2015-03-05 | E-GEOD-59487 | biostudies-arrayexpress

Mre11 suppresses replication stress and gene amplification proficiency

2015-03-05 | GSE59487 | GEO

Natural cycle frozen embryo transfer is superior to artificial cycle in women with recurrent implantation failure: endometrial transcriptome study

Project description:Transcriptome profile of receptive phase endometrium among infertile women with recurrent implantation failure (RIF) in two different endometrial preparation protocols for FET was analyzed: natural cycle (NC-FET) vs. artificial cycle (AC-FET). Fifteen endometrial biopsy samples were obtained: women with unexplained RIF (n = 5) in natural cycles for FET (NC-FET), women with unexplained RIF undergoing artificial endometrial preparation (n = 5) for FET (AC-FET), and healthy women (n = 5) with proven fertility in natural cycles (NC-FC) (Control group). All endometrial biopsies were obtained during the mid-secretory phase, at the time of ‘window of implantation’.

2016-01-15 | E-MTAB-3655 | biostudies-arrayexpress

Natural cycle frozen embryo transfer is superior to artificial cycle in women with recurrent implantation failure: endometrial transcriptome study

2015-10-28 | E-MTAB-3713 | biostudies-arrayexpress

GMI Proficiency Test

Project description:Global Microbial Identifier Proficiency Test

| PRJEB21132 | ENA