Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Growth of the maternal intestine during pregnancy and lactation [gut epithelium]

ABSTRACT: Growth of the maternal intestine during pregnancy and lactation [gut epithelium]

PROVIDER: PRJNA1040913 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR26844131_1.fastq.gz	Fastqsanger.gz
	SRR26844131_2.fastq.gz	Fastqsanger.gz
	SRR26844132_1.fastq.gz	Fastqsanger.gz
	SRR26844132_2.fastq.gz	Fastqsanger.gz
	SRR26844133_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 108

Similar Datasets

Growth of the maternal intestine during pregnancy and lactation [gut pregnancy]

Project description:Growth of the maternal intestine during pregnancy and lactation [gut pregnancy]

| PRJNA1040921 | ENA

Growth of the maternal intestine during pregnancy and lactation

Project description:Growth of the maternal intestine during pregnancy and lactation

| PRJNA1040918 | ENA

Growth of the maternal intestine during pregnancy and lactation [Xenium]

Project description:Growth of the maternal intestine during pregnancy and lactation [Xenium]

| PRJNA1201083 | ENA

Growth of the maternal intestine during pregnancy and lactation [scRNA gut]

Project description:Growth of the maternal intestine during pregnancy and lactation [scRNA gut]

| PRJNA1040924 | ENA

Growth of the maternal intestine during pregnancy and lactation [gut sections]

Project description:Growth of the maternal intestine during pregnancy and lactation [gut sections]

| PRJNA1040926 | ENA

Growth of the maternal intestine during pregnancy and lactation [Xenium]

Project description:The organs of many female animals grow and are metabolically remodelled by reproduction; this process has been historically overlooked. Using the intestine of mouse mothers, a striking and genetically tractable example of reproductive organ resizing, we find that reproductive intestinal remodelling is anticipatory and distinct from diet- or microbiota-induced intestinal resizing. Reproductive remodelling involves partially irreversible elongation of the intestine and fully reversible growth of its epithelium, which ensues from an expansion of the isthmus progenitors, increased progenitor proliferation and accelerated migration of differentiated cells. Through spatiotemporal analysis of gene expression, we identify induction of the SGLT3a transporter in a subset of enterocytes as one of the earliest reproductive hallmarks within the intestinal epithelium. Electrophysiological and genetic interrogations in vivo and in organoids indicate that SGLT3a does not sustain broad digestive functions or enterocyte health. Instead, SGLT3a detects protons and sodium to extrinsically support the expansion of adjacent Fgfbp1-positive isthmus progenitors and gut epithelial growth during reproduction. Our findings reveal unanticipated molecular, cell and organ specificity to physiological organ remodelling, raising the possibility that organ- and state-specific growth programmes could be leveraged to improve pregnancy outcomes or prevent maladaptive consequences of such growth.

2025-03-19 | GSE285027 | GEO

Effect of lactation and location relative to the corpus luteum on the transcriptome of the bovine oviduct epithelium

Project description:Lactation and associated metabolic stresses during the post-partum period have been shown to impair fertility in dairy cows. The oviduct plays key roles in embryo development and the establishment of pregnancy in cattle. The aim of this study was to investigate the effects of lactation and location relative to the corpus luteum (CL) on the transcriptome of the bovine oviduct epithelium.

2019-01-07 | GSE124110 | GEO

Profiling immune cells in the mammary gland during pregnancy and lactation

Project description:The mammary gland undergoes profound structural and cellular changes during pregnancy and lactation, yet the changes in immunocyte populations are incompletely understood. We identified changes in all immunocyte populations including B cells, NK cells, myeloid cells, and T cells, specifically increases in CD4+ and CD8+ T effector cells in late pregnancy and lactation that are partly dependent on microbial signals.

2025-04-14 | GSE290256 | GEO

microRNA expression in postnatal mammary gland development -Pregnancy Day14 and Lactation day 2

Project description:Previoulsly miRNA expression profiling of the whole mammary gland across different stages of pregnancy and lactation has been performed in mice. Since mammary gland has both epithelial and stromal compartments, to specifically identify the miRNAs involved in the transition from pregnancy to lactation a process termed as secretory activation, expression profiling of isolated mammary epithelial cells (MECs) from four CD1 mice each at Pregnancy day 14 (P14) and Lactation day 2 (L2) was performed in the current study. Statistical analysis of the miRNA changes between P14 and L2 identified 32 miRNAs to be differentially expressed with a fold change greater than or equal to 2, of which, the majority of them declinied at the onset of lactation.

2016-10-05 | GSE79949 | GEO

Growth of the maternal intestine during pregnancy and lactation [gut epithelium]

Project description:The organs of female animals can be dramatically enlarged and metabolically remodelled by reproduction. The cellular changes and genetic programmes that initiate and sustain these transformations remain largely uncharacterised. It is also unclear whether the mechanisms that drive reproductive growth are shared between organs, or with other environmental triggers of adult organ growth. We have tackled these questions in mouse mothers, whose intestines provide a striking and genetically tractable example of reproductive organ resizing. We find that intestinal remodelling during reproduction is anticipatory of reproductive needs and distinct from diet-induced intestinal resizing.

2025-03-20 | GSE247923 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data