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Porcine PARP11 is essential for the proliferation of pseudorabies Virus

ABSTRACT: Porcine PARP11 is essential for the proliferation of pseudorabies Virus

PROVIDER: PRJNA1041334 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26849070_1.fastq.gz	Fastqsanger.gz
	SRR26849070_2.fastq.gz	Fastqsanger.gz
	SRR26849071_1.fastq.gz	Fastqsanger.gz
	SRR26849071_2.fastq.gz	Fastqsanger.gz
	SRR26849072_1.fastq.gz	Fastqsanger.gz

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Porcine ZC3H11A is essential for the proliferation of pseudorabies virus (PRV) and porcine circovirus 2 (PCV2) by mediating mRNA export

Project description:Porcine ZC3H11A is essential for the proliferation of pseudorabies virus (PRV) and porcine circovirus 2 (PCV2) by mediating mRNA export

| PRJNA803041 | ENA

Porcine PARP11 is essential for the proliferation of pseudorabies Virus

Project description:PRV infection in swine can cause devastating disease and pose a potential threat to humans. Advancing the interplay between PRV and host is essential to elucidate the pathogenic mechanism of PRV and identify novel anti-PRV targets. In this study, we identified PARP11 as a host factor that can significantly affect PRV infection. Inhibition of PARP11 and knockout of PARP11 can significantly promoted PRV infection. Subsequently, we further found that PARP11 knockout upregulated the transcription of NXF1 and CRM1, resulting in enhanced transcription of viral genes. Furthermore, we also found that PARP11 knockout could activate the autophagy pathway and suppress the mTOR pathway during PRV infection. These findings could provide insight into the mechanism in which PARP11 participated during PRV infection and offer a potential target to develop anti-PRV therapies.

2024-07-01 | GSE247973 | GEO

Strategies for the Enhanced Expression of Porcine RSAD2 against Pseudorabies Virus Infection

Project description:Strategies for the Enhanced Expression of Porcine RSAD2 against Pseudorabies Virus Infection

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Pseudorabies virus transcriptome sequencing

Project description:Characterization of pseudorabies virus transcriptome by Illumina sequencing

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Effects of Pseudorabies Virus Infection on the Tracheobronchial Lymph Node Transcriptome

Project description:RNA isolated from draining tracheobronchial lymph nodes (TBLN) from 5-week old pigs, either clinically infected with a feral isolate of Pseudorabies virus or uninfected were interrogated using Illumina Digital Gene Expression Tag Profiling. Over 100 million tag sequences were observed, representing 4,064,189 unique 21-base sequences collected from TBLN at time points 1, 3, 6 and 14 days post-infection (dpi) RNA isolated from draining tracheobronchial lymph nodes (TBLN) from 5-week old pigs (% per group pooled), either clinically infected with feral isolate FS268 of Pseudorabies virus or uninfected at 1, 3, 6, and 14 days post inoculation. Over 100 million tag sequences were observed, representing 4,064,189 unique 21-base sequences.

2015-10-30 | E-GEOD-74473 | biostudies-arrayexpress

Effects of Pseudorabies Virus Infection on the Tracheobronchial Lymph Node Transcriptome

2015-10-30 | GSE74473 | GEO

Transcription profiling of pig brain and lung to natural infection by Pseudorabies virus

Project description:Six piglets (age 2-4 days) suffering from pseudorabies virus were identified during at outbreak at a commercial farm. RNA was extracted from lung (n=4) and brain (n=6) of the infected pigs, and compared to lung/brain RNA from a control pool of three uninfected piglets. Expression profiling used a human oligonucleotide geneset.

2009-10-02 | E-MEXP-2376 | biostudies-arrayexpress

Porcine encephalomyocarditis virus

Project description:Porcine encephalomyocarditis virus vcDNA sequence in E14TG2a

| PRJNA596036 | ENA

iTRAQ-based phospho-proteomics identifies a critical role of ATF2 in pseudorabies virus replication

Project description:Pseudorabies virus (PRV), the etiological agent of Aujeszky’s disease, is a swine pathogen of the alphaherpesvirinae subfamily resulting in devastating neurological and respiratory disorders in piglets, or abortion in pregnant sows.Here, we performed isobaric tags for relative and absolute quantitation (iTRAQ) quantitative phosphoproteomics on PRV-infected PK-15 cells, which identified 5723 phospho-peptides, corresponding to 2180 proteins, including 810 proteins showing significant changes in phosphorylation level during early PRV infection.

2022-10-13 | PXD014685 | Pride

Porcine ZC3H11A is essential for the proliferation of pseudorabies virus (PRV) and porcine circovirus 2 (PCV2) by mediating mRNA export

Project description:Purpose:ZC3H11A has been reported to play a role in RNA transport. The purpose of this study was to detect the differentially expressed genes after ZC3H11A knockout. Methods: RNA sequencing was performed on PK-15 cell line (WT) and ZC3H11A-/- using Illumina platform, and three repeated RNA sequencing results were obtained. Results: Using an optimized data analysis workflow,different expression genes were obtained and RNA transport pathway was enriched through KEGG pathway analysis. Conclusions: In this study, we observed that ZC3H11A interacted with TRanscription and the EXport complex (TREX) and played an important role in mRNA export.

2022-02-06 | GSE196025 | GEO

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