Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Z-RNA drives Tau-mediated neurodegeneration of Alzheimer’s disease [RIP-Seq]

ABSTRACT: Z-RNA drives Tau-mediated neurodegeneration of Alzheimer’s disease [RIP-Seq]

PROVIDER: PRJNA1041716 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR26858077_1.fastq.gz	Fastqsanger.gz
	SRR26858077_2.fastq.gz	Fastqsanger.gz
	SRR26858078_1.fastq.gz	Fastqsanger.gz
	SRR26858078_2.fastq.gz	Fastqsanger.gz
	SRR26858079_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 6

Similar Datasets

Z-RNA drives Tau-mediated neurodegeneration of Alzheimer’s disease [RIP-Seq]

Project description:Tau aggregates lead to progressive neurodegeneration in Alzheimer’s disease (AD). Neuron death is one of the hallmarks of neurodegeneration.However, the pathological influence of neuronal death is undetermined, and the connection between Tau aggregates and neuronal death remains elusive. Here we demonstrated the essential role of neuron death in Tau-related neurodegeneration. Tau-neurons died in necroptosis, dependent on ZBP1 sensitized by Z-RNAs (an unusual left-handed conformation). Those endogenous Z-RNAs were transcripts of reactivated transposable elements (TEs) originally silenced in heterochromatin.

2023-11-22 | GSE248069 | GEO

Z-RNA drives Tau-mediated neurodegeneration of Alzheimer’s disease

Project description:Tau aggregates lead to progressive neurodegeneration in Alzheimer’s disease (AD). Neuron death is one of the hallmarks of neurodegeneration. However, the pathological influence of neuronal death is undetermined, and the connection between Tau aggregates and neuronal death remains elusive. Here we demonstrated the essential role of neuron death in Tau-related neurodegeneration. Tau-neurons died in necroptosis, dependent on ZBP1 sensitized by Z-RNAs (an unusual left-handed conformation). Those endogenous Z-RNAs were transcripts of reactivated transposable elements (TEs) originally silenced in heterochromatin.

2026-03-14 | GSE306739 | GEO

Z-RNA drives Tau-mediated neurodegeneration of Alzheimer’s disease

Project description:Z-RNA drives Tau-mediated neurodegeneration of Alzheimer’s disease

| PRJNA1041713 | ENA

Z-RNA drives Tau-mediated neurodegeneration of Alzheimer’s disease

Project description:Z-RNA drives Tau-mediated neurodegeneration of Alzheimer’s disease

| PRJNA1312008 | ENA

Z-RNA drives Tau-mediated neurodegeneration of Alzheimer’s disease [lncRNA-Seq]

Project description:Tau aggregates lead to progressive neurodegeneration in Alzheimer’s disease (AD) (ref). Neuron death is one of the hallmarks of neurodegeneration (ref). However, the pathological influence of neuronal death is undetermined, and the connection between Tau aggregates and neuronal death remains elusive. Here we demonstrated the essential role of neuron death in Tau-related neurodegeneration. Tau-neurons died in necroptosis, dependent on ZBP1 sensitized by Z-RNAs (an unusual left-handed conformation). Those endogenous Z-RNAs were transcripts of reactivated transposable elements (TEs) originally silenced in heterochromatin.

2023-11-22 | GSE248068 | GEO

Z-RNA drives Tau-mediated neurodegeneration of Alzheimer’s disease [ChIP-Seq]

Project description:Tau aggregates lead to progressive neurodegeneration in Alzheimer’s disease (AD). Neuron death is one of the hallmarks of neurodegeneration. However, the pathological influence of neuronal death is undetermined, and the connection between Tau aggregates and neuronal death remains elusive. Here we demonstrated the essential role of neuron death in Tau-related neurodegeneration. Tau-neurons died in necroptosis, dependent on ZBP1 sensitized by Z-RNAs (an unusual left-handed conformation). Those endogenous Z-RNAs were transcripts of reactivated transposable elements (TEs) originally silenced in heterochromatin.

2026-03-14 | GSE306751 | GEO