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Analyzing gene expression profiles in the liver of miR-137 knockout mice versus wild-type mice

ABSTRACT: Analyzing gene expression profiles in the liver of miR-137 knockout mice versus wild-type mice

PROVIDER: PRJNA1043138 | ENA |

REPOSITORIES: ENA

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Analyzing gene expression profiles in the brain of miR-137 knockout mice versus wild-type mice

Project description:Analyzing gene expression profiles in the brain of miR-137 knockout mice versus wild-type mice

| PRJNA1045574 | ENA

Analyzing gene expression profiles in the brain of miR-137 knockout mice versus wild-type mice

Project description:We conducted this experiment using mice with a systemic knockout of miR-137. At 14 days post-birth, we sacrificed the mice and extracted key organs, including the brain. To assess the impact of miR-137 knockout on brain gene expression, we extracted RNA from the livers of both wild-type and knockout mice and analyzed it using microarray.

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Analyzing gene expression profiles in the liver of miR-137 knockout mice versus wild-type mice

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TMT-based quantitative analysis of brain whole proteome of miR-137 mouse models

Project description:Recent genetic evidence has revealed microRNA-137 (miR-137) as a risk gene in schizophrenia and autism spectrum disorder (ASD), and the following cellular studies have demonstrated the importance of miR-137 in regulating neurogenesis. We have generated miR-137 knockout mice which display behaviors that resemble some symptoms of these two diseases. To investigate the underlying molecular mechanism, we performed comprehensive analyses of the entire RNA and protein molecules of the miR-137 mouse brains. The dataset uploaded here is the raw data of the mass spectrometry-based whole proteome analysis of the six miR-137 mouse brains: wild-type, heterozygous (miR-137+/–) and homozygous (miR-137–/–) from two different litters. The tandem mass tag (TMT) methodology was employed in this proteomics analysis for the quantitation. The sample channels are: 128C (miR-137+/+, litter 1), 129N (miR-137+/–, litter 1), 129C (miR-137–/–, litter 1), 130N (miR-137+/+, litter 2), 130C (miR-137+/–, litter 2), and 131N (miR-137–/–, litter 2).

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