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ABSTRACT: Prevotella copri anti- hyperglycemia

PROVIDER: PRJNA1043404 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26905806_1.fastq.gz	Fastqsanger.gz
	SRR26905806_2.fastq.gz	Fastqsanger.gz
	SRR26905807_1.fastq.gz	Fastqsanger.gz
	SRR26905807_2.fastq.gz	Fastqsanger.gz
	SRR26905808_1.fastq.gz	Fastqsanger.gz

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Prevotella copri facilitates wound healing in mice through the sphingosine-CerS1-ceramide metabolic pathway

Project description:Skin wound repair constitutes a sophisticated biological process involving spatiotemporally coordinated molecular cascades, with emerging evidence highlighting the dynamic regulatory role of skin microbiota. Utilizing a broad-spectrum antibiotic-treated (ABX) murine model, we identified Prevotella copri as a core functional commensal in the wound microecosystem that orchestrates tissue regeneration through metabolite-host crosstalk. ABX-induced microbial remodeling significantly enriched P. copri relative abundance, accelerated wound closure, and upregulated pro-regenerative factors VEGF and FGF-2. Metabolomic profiling revealed that P. copri-secreted sphingosine undergoes bioconversion to C18-ceramide via the non-canonical CerS1 pathway, driving keratinocyte hyperproliferation and neoangiogenesis. Pharmacological inhibition of CerS1 with P053 suppressed ceramide synthesis and delayed healing, mechanistically validating the sphingosine-CerS1-ceramide axis. Crucially, P. copri exhibits dual regulatory modalities: ecologically, β-lactamase-mediated antibiotic resistance establishes microbial dominance, while metabolically, sphingolipid-driven spatiotemporal signaling remodels the regenerative microenvironment. This paradigm shifts the pathocentric view of wound microbiota, proposing a synergistic strategy combining "functional microbiota enrichment" and "metabolic axis targeting". Our findings elucidate a microecology-metabolism circuit that transitions wound management from passive anti-infection to precision intervention, providing a molecular blueprint for developing microbiome-reprogramming therapies in regenerative medicine.

2025-10-28 | GSE296532 | GEO

Segatella copri

Project description:Prevotella copri overview

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Segatella copri

Project description:Prevotella copri Metagenomic assembly

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Segatella copri CAG:164

Project description:Prevotella copri CAG:164 overview

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Project description:Identification of Prevotella copri glycan utilization systems

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Project description:Anti-inflammatory response to 1,8-Cineol is associated with colonic presence of Prevotella copri in Otitis media patients

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Prevotella copri mediated caffeine metabolism involves ferroptosis of osteoblasts in osteoarthritis

Project description:<p>There is positive causality between coffee consumption and osteoarthritis (OA), however, whether gut microbiota is involved in it needs to be discussed. Here, we observed that, in caffeine consumers, fecal Prevotella copri (P. copri) abundance was positively correlated with subchondral bone mass, serum caffeine concentration was negatively correlated with bone mass, and fecal P. copri was negatively correlated with serum caffeine. In OA model, caffeine intake aggravated articular cartilage destruction, bone mass loss and intestinal barrier damage, on the contrary, paraxanthine intake, reversed the above lesions. Importantly, after intestinal P. copri supplement, caffeine induced lesions in OA mice was effectively alleviated. Mechanically, P. copri has the potential to metabolize caffeine into paraxanthine, and this effect could alleviate the ferroptosis of osteoblast in OA model. This study screened out that P. copri, an endogenous bacteria, has the ability to metabolize caffeine and revealed the effects of it on OA progression.</p>

2025-03-21 | MTBLS11685 | MetaboLights

Project description:Acetate-producing Prevotella copri aggravates schizophrenia behavior by modulating serotonin metabolism

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Project description:Acetate-producing Prevotella copri aggravates schizophrenia behavior by modulating serotonin metabolism

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Specific targeting of intestinal Prevotella copri by a Listeria monocytogenes bacteriocin

Project description:Specific targeting of intestinal Prevotella copri by a Listeria monocytogenes bacteriocin

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