Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

C/EBPβ-induced lymphoid-to-myeloid transdifferentiation emulates granulocyte-monocyte progenitor (GMP) biology

ABSTRACT: C/EBPβ-induced lymphoid-to-myeloid transdifferentiation emulates granulocyte-monocyte progenitor (GMP) biology

PROVIDER: PRJNA1043711 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR26907590.fastq.gz	Fastqsanger.gz
	SRR26907591.fastq.gz	Fastqsanger.gz
	SRR26907592.fastq.gz	Fastqsanger.gz
	SRR26907593.fastq.gz	Fastqsanger.gz
	SRR26907594.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 8

Similar Datasets

C/EBPβ-induced lymphoid-to-myeloid transdifferentiation emulates granulocyte-monocyte progenitor (GMP) biology

Project description:The CCAAT/enhancer-binding-protein beta (C/EBPβ) induces primary v-Abl immortalized mouse B cell transdifferentiation (BT) into granulocyte-macrophage-progenitor-like cells (GMPBT). GMPBT maintain cytokine independent self-renewal, lineage choice, and multi-lineage differentiation. Single cell transcriptomics now shows that GMPBT comprise a continuum of myelomonopoietic differentiation states that seamlessly fit into state-to-fate maps of normal GMP. Inactivation of the v-Abl kinase unveiled dependence on activated CSF2-Jak2-Stat5 signaling. Deletion of IRF8 diminished monopoiesis and enhanced granulopoiesis while removal of C/EBPβ abrogated self-renewal and granulopoiesis yet permitted macrophage differentiation. The GMPBT cell culture system is easily scalable to explore the basics of GMP biology and lineage commitment and largely reduces ethically and legislatively arguable, labor-intensive, and costly animal experiments.

2023-11-24 | GSE248415 | GEO

AML patient granulocyte macrophage progenitor (GMP) cells

Project description:AML patient granulocyte macrophage progenitor (GMP) cells

| PRJNA678010 | ENA

C/EBPβ-induced lymphoid-to-myeloid transdifferentiation emulates granulocyte-monocyte progenitor biology.

Project description:CCAAT/enhancer-binding protein beta (C/EBPβ) induces primary v-Abl immortalized mouse B cells to transdifferentiate (BT, B cell transdifferentiation) into granulocyte-macrophage progenitor-like cells (GMPBTs). GMPBTs maintain cytokine-independent self-renewal, lineage choice, and multilineage differentiation. Single-cell transcriptomics demonstrated that GMPBTs comprise a continuum of myelomonopoietic differentiation states that seamlessly fit into state-to-fate maps of normal granulocyte-macrophage progenitors (GMPs). Inactivating v-Abl kinase revealed the dependence on activated CSF2-JAK2-STAT5 signaling. Deleting IRF8 diminished monopoiesis and enhanced granulopoiesis while removing C/EBPβ-abrogated self-renewal and granulopoiesis but permitted macrophage differentiation. The GMPBT culture system is easily scalable to explore the basics of GMP biology and lineage commitment and largely reduces ethically and legislatively debatable, labor-intensive, and costly animal experiments.

| S-EPMC10828814 | biostudies-literature

AML patient granulocyte macrophage progenitor (GMP) cells [human]

Project description:AML patient granulocyte macrophage progenitor (GMP) cells [human]

| PRJNA631276 | ENA

Molecular reprogramming of granulocyte/macrophage progenitor (GMP) clusters

Project description:Molecular reprogramming of granulocyte/macrophage progenitor (GMP) clusters

| PRJNA355977 | ENA

Mouse inv(16):TET2ko granulocyte macrophage progenitor (GMP) cells

Project description:Mouse inv(16):TET2ko granulocyte macrophage progenitor (GMP) cells

| PRJNA678011 | ENA

EP - GMP

Project description:Mouse erythroid progenitors (EP) in comparison to granulocyte/monocyte - macrophage progenitors (GMP) from 10 - 16 week old C57/Bl6 - S129Ola (mixed genetic background) purified by flow cytometry Keywords = EP Keywords = GMP Keywords = hematopoiesis Keywords: other

2004-10-22 | GSE1584 | GEO

Transcription profiling of mouse erythroid progenitors (EP) in comparison to granulocyte/monocyte - macrophage progenitors (GMP) from 10 - 16 week old C57/Bl6 - S129Ola

2008-06-11 | E-GEOD-1584 | biostudies-arrayexpress

WT and inv(16)/KITD816Y granulocyte macrophage progenitor (GMP) cells [mouse]

Project description:WT and inv(16)/KITD816Y granulocyte macrophage progenitor (GMP) cells [mouse]

| PRJNA631277 | ENA

Granulocyte-monocyte progenitor (GMP) RNA-seq in wild type and MST1-deficient mice.

Project description:Granulocyte-monocyte progenitor (GMP) RNA-seq in wild type and MST1-deficient mice.

| PRJNA879324 | ENA