Project description:AML patient GMPs or CMPs were FACS sorted as described in Supplementary Information (Reckzeh, K et al. 2020) TET2 deficiency cooperates with CBFB-MYH11 to induce acute myeloid leukemia and represents an early leukemogenic event. Reckzeh, K et al

2022-03-28 | GSE161391 | GEO

Mouse inv(16):TET2ko granulocyte macrophage progenitor (GMP) cells

Project description:Mouse inv(16):TET2ko granulocyte macrophage progenitor (GMP) cells

| PRJNA678011 | ENA

AML patient granulocyte macrophage progenitor (GMP) cells [human]

Project description:AML patient GMPs or CMPs were FACS sorted as described in material and methods from supplementary data (Estruch M et al 2020)

2020-11-09 | GSE150159 | GEO

WT and inv(16)/KITD816Y granulocyte macrophage progenitor (GMP) cells [mouse]

Project description:WT and inv(16)/KITD816Y granulocyte macrophage progenitor (GMP) cells [mouse]

| PRJNA631277 | ENA

C/EBPβ-induced lymphoid-to-myeloid transdifferentiation emulates granulocyte-monocyte progenitor (GMP) biology

Project description:The CCAAT/enhancer-binding-protein beta (C/EBPβ) induces primary v-Abl immortalized mouse B cell transdifferentiation (BT) into granulocyte-macrophage-progenitor-like cells (GMPBT). GMPBT maintain cytokine independent self-renewal, lineage choice, and multi-lineage differentiation. Single cell transcriptomics now shows that GMPBT comprise a continuum of myelomonopoietic differentiation states that seamlessly fit into state-to-fate maps of normal GMP. Inactivation of the v-Abl kinase unveiled dependence on activated CSF2-Jak2-Stat5 signaling. Deletion of IRF8 diminished monopoiesis and enhanced granulopoiesis while removal of C/EBPβ abrogated self-renewal and granulopoiesis yet permitted macrophage differentiation. The GMPBT cell culture system is easily scalable to explore the basics of GMP biology and lineage commitment and largely reduces ethically and legislatively arguable, labor-intensive, and costly animal experiments.

2023-11-24 | GSE248415 | GEO

C/EBPβ-induced lymphoid-to-myeloid transdifferentiation emulates granulocyte-monocyte progenitor (GMP) biology

Project description:C/EBPβ-induced lymphoid-to-myeloid transdifferentiation emulates granulocyte-monocyte progenitor (GMP) biology

| PRJNA1043711 | ENA

Granulocyte-monocyte progenitor (GMP) RNA-seq in wild type and MST1-deficient mice.

Project description:Granulocyte-monocyte progenitor (GMP) RNA-seq in wild type and MST1-deficient mice.

| PRJNA879324 | ENA