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Single cell RNA-Seq result of spinal cord of AR-97Q mice and wild-type mice at four disease stages

ABSTRACT: Single cell RNA-Seq result of spinal cord of AR-97Q mice and wild-type mice at four disease stages

PROVIDER: PRJNA1045588 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26959325.fastq.gz	Fastqsanger.gz
	SRR26959326.fastq.gz	Fastqsanger.gz
	SRR26959327.fastq.gz	Fastqsanger.gz
	SRR26959328.fastq.gz	Fastqsanger.gz
	SRR26959329.fastq.gz	Fastqsanger.gz

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RNA-seq of sipinal cord of WT, AR-24Q, AR-97Q, testosterone-treated AR-97Q mice, Scramble-ASO-treated AR-97Q mice, and Rest4-ASO #3-treated AR-97Q mice at P7

Project description:Testosterone (20 mg) was subcutaneously adminstered to AR-97Q mice at postnatal day 1 (P1). Scramble-ASO and Rest4-ASO #3 were intracerebroventriculary administred to AR-97Q mice at P1.Gene expression profiles were analysed in the spinal cord of WT, AR-24Q, AR-97Q, testosterone-treated AR-97Q mice, Scramble-ASO-treated AR-97Q mice, and Rest4-ASO #3-treated AR-97Q mice at P7.

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Single cell RNA-Seq result of spinal cord of AR-97Q mice and AR-24Q mice at 6 weeks

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Single cell RNA-Seq result of spinal cord of AR-97Q mice and wild-type mice at four disease stages

Project description:To understand the early pathogenesis of SBMA and to systematically assess the role of different cells in the spinal cord of SBMA, we conducted snRNA-seq on the spinal cord of AR-97Q mice at different stages of the disease. The genes related to ion channel and synapse function were up-regulated in oligodendrocytes in early stages of SBMA although they were down-regulated at the advanced stage.

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