Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Single cell RNA-Seq result of spinal cord of AR-97Q mice and AR-24Q mice at 6 weeks

ABSTRACT: Single cell RNA-Seq result of spinal cord of AR-97Q mice and AR-24Q mice at 6 weeks

PROVIDER: PRJNA1198625 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR31724600.fastq.gz	Fastqsanger.gz
	SRR31724601.fastq.gz	Fastqsanger.gz

Items per page:

1 - 2 of 2

Similar Datasets

Single cell RNA-Seq result of spinal cord of AR-97Q mice and AR-24Q mice at 6 weeks

Project description:To understand the early pathogenesis of SBMA and to systematically assess the role of different cells in the spinal cord of SBMA, we conducted snRNA-seq on the spinal cord of AR-97Q and AR-24Q mice at 6 weeks. The genes related to ion channel and synapse function were up-regulated in oligodendrocytes of AR-97Q mice.

2024-12-29 | GSE284338 | GEO

RNA-seq of sipinal cord of WT, AR-24Q, AR-97Q, testosterone-treated AR-97Q mice, Scramble-ASO-treated AR-97Q mice, and Rest4-ASO #3-treated AR-97Q mice at P7

Project description:Testosterone (20 mg) was subcutaneously adminstered to AR-97Q mice at postnatal day 1 (P1). Scramble-ASO and Rest4-ASO #3 were intracerebroventriculary administred to AR-97Q mice at P1.Gene expression profiles were analysed in the spinal cord of WT, AR-24Q, AR-97Q, testosterone-treated AR-97Q mice, Scramble-ASO-treated AR-97Q mice, and Rest4-ASO #3-treated AR-97Q mice at P7.

2026-02-08 | GSE286003 | GEO

Single-nucleus RNA-seq results of AR-97Q and AR-24Q mice at 8 weeks of age.

Project description:To understand the early pathogenesis of motor neuron degeneration in spinal and bulbar muscular atrophy (SBMA), we conducted single-nucleus RNA-seq (snRNA-seq) on the spinal cords of AR-97Q and AR-24Q mice at 8 weeks of age. REST target genes were up-regulated in motor neurons of AR-97Q mice.

2026-02-08 | GSE306468 | GEO

RNA-seq of sipinal cord of AR-97Q and WT mice at P7 and 13 weeks of age

Project description:Antisense oligonuleotides targeting human AR (AR-ASO) or Rest4 (Rest4-ASO) are intracerebroventriculary injected to AR-97Q mice at postnatal day 1 (P1). Gene expression profiles were analysed in the spinal cord of WT and AR-97Q mice at P7 and 13 weeks of age.

2026-02-08 | GSE261519 | GEO

RNA-seq of sipinal cord of WT, AR-24Q, AR-97Q, testosterone-treated AR-97Q mice, Scramble-ASO-treated AR-97Q mice, and Rest4-ASO #3-treated AR-97Q mice at P7

Project description:RNA-seq of sipinal cord of WT, AR-24Q, AR-97Q, testosterone-treated AR-97Q mice, Scramble-ASO-treated AR-97Q mice, and Rest4-ASO #3-treated AR-97Q mice at P7

| PRJNA1207460 | ENA

Single-nucleus RNA-seq results of AR-97Q and AR-24Q mice at 8 weeks of age.

Project description:Single-nucleus RNA-seq results of AR-97Q and AR-24Q mice at 8 weeks of age.

| PRJNA1310867 | ENA

Single cell RNA-Seq result of spinal cord of AR-97Q mice and wild-type mice at four disease stages

Project description:To understand the early pathogenesis of SBMA and to systematically assess the role of different cells in the spinal cord of SBMA, we conducted snRNA-seq on the spinal cord of AR-97Q mice at different stages of the disease. The genes related to ion channel and synapse function were up-regulated in oligodendrocytes in early stages of SBMA although they were down-regulated at the advanced stage.

2023-11-27 | GSE248684 | GEO

Single cell RNA-Seq result of spinal cord of AR-97Q mice and wild-type mice at four disease stages

Project description:Single cell RNA-Seq result of spinal cord of AR-97Q mice and wild-type mice at four disease stages

| PRJNA1045588 | ENA

RNA-Seq results of oligodendrocyte model of SBMA, AR-97Q cells, compared to AR-17Q cells

Project description:Transcriptional changes of AR-97Q cells and AR-17Q cells were compared. RNA-seq gene expression analysis revealed that differentially expressed genes were associated with regulation of signaling and regulation of cell communication as biological process, and membrane was most relevant to the genes as cellular component.

2023-11-14 | GSE247374 | GEO

RNA-seq of sipinal cord of AR-97Q and WT mice at P7 and 13 weeks of age

Project description:RNA-seq of sipinal cord of AR-97Q and WT mice at P7 and 13 weeks of age

| PRJNA1087370 | ENA