Protracted Neuronal Recruitment in the Temporal Lobe of Young Children
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PROVIDER: PRJNA1057453 | ENA |
REPOSITORIES: ENA
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Project description:Protracted Neuronal Recruitment in the Temporal Lobe of Young Children
| PRJNA1057452 | ENA
Project description:Protracted neuronal recruitment in the temporal lobe of young children
| PRJNA821464 | ENA
Project description:The human brain's temporal lobe contains the entorhinal cortex (EC), a highly interconnected integrative hub for sensory and spatial information; key for episodic memory formation and the primary source of cortical hippocampal inputs. The human EC continues to develop during childhood, yet neurogenesis and neuronal migration to the EC are widely considered complete by birth. Here we show that the human temporal lobe contains many young neurons migrating into the postnatal EC and adjacent regions; with a large tangential stream persisting ~1 year and radial dispersal until ~2-3 years. In contrast, we found no equivalent postnatal migration in rhesus macaque (Macaca mulatta). Immunostaining and single-nuclei RNA-seq (snRNA-seq) of ganglionic eminence (GE) germinal zones, EC stream, and postnatal EC reveals that most EC stream migrating cells are derived from the caudal GE and become LAMP5+RELN+ inhibitory interneurons. These late-arriving interneurons could continue to shape the processing of sensory and spatial information well into postnatal life when children are actively interacting with their environment. The EC is one of the first brain regions affected in Alzheimer’s disease and recent work links the decline in cognitive function to the loss of LAMP5+RELN+ cells. Our investigation reveals that many of these cells arrive in the EC through a major postnatal migratory stream in early childhood.
2023-09-26 | GSE199762 | GEO
Project description:The temporal lobe of the human brain contains the entorhinal cortex (EC). This region of the brain is a highly interconnected integrative hub for sensory and spatial information; it also has a key role in episodic memory formation and is the main source of cortical hippocampal inputs1-4. The human EC continues to develop during childhood5, but neurogenesis and neuronal migration to the EC are widely considered to be complete by birth. Here we show that the human temporal lobe contains many young neurons migrating into the postnatal EC and adjacent regions, with a large tangential stream persisting until the age of around one year and radial dispersal continuing until around two to three years of age. By contrast, we found no equivalent postnatal migration in rhesus macaques (Macaca mulatta). Immunostaining and single-nucleus RNA sequencing of ganglionic eminence germinal zones, the EC stream and the postnatal EC revealed that most migrating cells in the EC stream are derived from the caudal ganglionic eminence and become LAMP5+RELN+ inhibitory interneurons. These late-arriving interneurons could continue to shape the processing of sensory and spatial information well into postnatal life, when children are actively interacting with their environment. The EC is one of the first regions of the brain to be affected in Alzheimer's disease, and previous work has linked cognitive decline to the loss of LAMP5+RELN+ cells6,7. Our investigation reveals that many of these cells arrive in the EC through a major postnatal migratory stream in early childhood.
| S-EPMC10901738 | biostudies-literature
Project description:Ion channel splice array data collected from temporal neocortex brain tissue collected from patients with mesial temporal lobe epilepsy. Temporal cortex samples from control subjects were compared to temporal neocortex of patients with mesial temporal lobe epilepsy
2010-06-11 | E-GEOD-6773 | biostudies-arrayexpress
Project description:Ion channel splice array data from temporal cortex brain tissue samples collected from control subjects (no mesial temporal lobe epilepsy). Keywords: disease associated splicing changes Temporal cortex samples from control subjects were compared to temporal neocortex of patients with mesial temporal lobe epilepsy
2007-01-23 | E-GEOD-6771 | biostudies-arrayexpress
Project description:Temporal Lobe Epilepsy and Retrotransposons
| PRJNA647483 | ENA
Project description:Temporal Lobe Epilepsy and Retrotransposons
| PRJNA647484 | ENA
Project description:This SuperSeries is composed of the following subset Series: GSE6771: Temporal Cortex Control (mesial temporal lobe epilepsy control) GSE6773: Temporal neocortex mesial temporal lobe epilepsy GSE6774: Temporal Cortex Control (Alzheimer's disease control) GSE6775: Temporal Cortex Alzheimer's Disease GSE6777: Cerebellum Alzheimer's Disease GSE6778: Cerebellum Control (Alzheimer's disease control) Keywords: SuperSeries Refer to individual Series
2007-01-23 | E-GEOD-6834 | biostudies-arrayexpress
Project description:Ion channel splice array data collected from temporal neocortex brain tissue collected from patients with mesial temporal lobe epilepsy. Keywords: disease associated splicing changes
2007-01-23 | GSE6773 | GEO