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Mixed patterns of intergenerational DNA methylation inheritance in Acropora

ABSTRACT: Mixed patterns of intergenerational DNA methylation inheritance in Acropora

PROVIDER: PRJNA1063351 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR27497800_1.fastq.gz	Fastqsanger.gz
	SRR27497800_2.fastq.gz	Fastqsanger.gz
	SRR27497801_1.fastq.gz	Fastqsanger.gz
	SRR27497801_2.fastq.gz	Fastqsanger.gz
	SRR27497802_1.fastq.gz	Fastqsanger.gz

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Mixed patterns of intergenerational DNA methylation inheritance in Acropora

Project description:For sessile organisms at high risk from climate change, phenotypic plasticity can be critical to rapid acclimation. Epigenetic markers like DNA methylation are hypothesized as mediators of plasticity; methylation is associated with the regulation of gene expression, can change in response to ecological cues, and is a proposed basis for the inheritance of acquired traits. Within reef-building corals, gene body methylation can change in response to ecological stressors. If coral DNA methylation is transmissible across generations, this could potentially facilitate rapid acclimation to environmental change. We investigated methylation heritability in Acropora, a stony reef-building coral. Two A. millepora and two A. selago adults were crossed, producing eight offspring crosses (four hybrid, two of each species). We used whole-genome bisulfite sequencing to identify methylated loci and allele-specific alignments to quantify per-locus inheritance. If methylation is heritable, differential methylation (DM) between the parents should equal DM between paired offspring alleles at a given locus. We found a mixture of heritable and non-heritable loci, with heritable portions ranging from 44% to 90% among crosses. Gene body methylation was more heritable than intergenic methylation, and most loci had a consistent degree of heritability between crosses (i.e., the deviation between parental and offspring DM were of similar magnitude and direction). Our results provide evidence that coral methylation can be inherited but that heritability is heterogenous throughout the genome. Future investigations into this heterogeneity and its phenotypic implications will be important to understanding the potential capability of intergenerational environmental acclimation in reef building corals."

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